{"id":16078,"date":"2019-02-06T09:36:48","date_gmt":"2019-02-06T09:36:48","guid":{"rendered":"https:\/\/www.elza-institute.com\/?p=13763"},"modified":"2020-10-02T15:43:47","modified_gmt":"2020-10-02T15:43:47","slug":"cxl-in-the-usa-part-4-the-future","status":"publish","type":"post","link":"https:\/\/www.elza-institute.com\/pt\/cxl-in-the-usa-part-4-the-future\/","title":{"rendered":"Cross-Linking nos EUA - Parte 4: O futuro"},"content":{"rendered":"<h2><strong>PACK-CXL<\/strong><\/h2>\n<figure id=\"attachment_13766\" aria-describedby=\"caption-attachment-13766\" style=\"width: 300px\" class=\"wp-caption alignleft\"><img decoding=\"async\" class=\"size-medium wp-image-13766\" src=\"https:\/\/www.elza-institute.com\/wp-content\/uploads\/2020\/10\/pack-cxl-illustration-300x108-1.jpg\" alt=\"Primeiro painel. Imagem de uma dupla h\u00e9lice de ADN. O texto \u00e9: intera\u00e7\u00e3o do ADN - impede a replica\u00e7\u00e3o; segundo painel: impedimento est\u00e9rico, resiste \u00e0 digest\u00e3o (texto por baixo de uma imagem de uma c\u00f3rnea reticulada que mostra fibrilhas reticuladas da c\u00f3rnea). \u00daltimo painel: stress oxidativo - s\u00e3o representadas esp\u00e9cies reactivas de oxig\u00e9nio que atacam bact\u00e9rias semelhantes a bastonetes.\" width=\"300\" height=\"108\" \/><figcaption id=\"caption-attachment-13766\" class=\"wp-caption-text\">Tr\u00eas m\u00e9todos pelos quais o PACK-CXL exerce o seu efeito antimicrobiano.<\/figcaption><\/figure>\n<p>O processo de reticula\u00e7\u00e3o da c\u00f3rnea envolve duas importantes ac\u00e7\u00f5es antimicrobianas. A primeira \u00e9 um efeito direto de elimina\u00e7\u00e3o dos agentes patog\u00e9nicos: A ilumina\u00e7\u00e3o UV n\u00e3o s\u00f3 pode matar os agentes patog\u00e9nicos, como a fotoactiva\u00e7\u00e3o da riboflavina para um estado excitado leva a que esta reaja com o oxig\u00e9nio ambiente, criando esp\u00e9cies reactivas de oxig\u00e9nio, que tamb\u00e9m podem danificar o ADN microbiano e as membranas citoplasm\u00e1ticas. O segundo efeito \u00e9 um efeito secund\u00e1rio do enrijecimento da c\u00f3rnea: as liga\u00e7\u00f5es cruzadas adicionais entre as mol\u00e9culas (principalmente de colag\u00e9nio) no estroma tornam o tecido mais resistente \u00e0 degrada\u00e7\u00e3o enzim\u00e1tica microbiana - e, por conseguinte, mais dif\u00edcil de propagar a doen\u00e7a. Esta utiliza\u00e7\u00e3o de liga\u00e7\u00f5es cruzadas para o tratamento da queratite infecciosa foi designada por \"crom\u00f3foro fotoactivado para a queratite\", ou PACK-CXL, e tem-se revelado muito promissora no tratamento de infec\u00e7\u00f5es da c\u00f3rnea em avalia\u00e7\u00f5es cl\u00ednicas realizadas at\u00e9 \u00e0 data.<\/p>\n<h3><strong>Reticula\u00e7\u00e3o personalizada<\/strong><\/h3>\n<figure id=\"attachment_13767\" aria-describedby=\"caption-attachment-13767\" style=\"width: 300px\" class=\"wp-caption alignright\"><img decoding=\"async\" class=\"size-medium wp-image-13767\" src=\"https:\/\/www.elza-institute.com\/wp-content\/uploads\/2020\/10\/Customized-CXL-300x150-1.jpg\" alt=\"Quatro c\u00edrculos conc\u00eantricos s\u00e3o colocados sobre a parte mais \u00edngreme do cone. Isto deixa tr\u00eas zonas - a zona mais interior est\u00e1 identificada com 10J\/cm2; a zona interm\u00e9dia est\u00e1 identificada com 7,2 J\/cm2 e a zona mais exterior est\u00e1 identificada com 5,4J\/cm2.\" width=\"300\" height=\"150\" \/><figcaption id=\"caption-attachment-13767\" class=\"wp-caption-text\">A reticula\u00e7\u00e3o personalizada \u00e9 conseguida centrando a ilumina\u00e7\u00e3o no cone e concentrando a energia UV mais no v\u00e9rtice do cone do que nas \u00e1reas circundantes.<\/figcaption><\/figure>\n<p>Como o CXL pode aplanar a c\u00f3rnea, e a c\u00f3rnea \u00e9 respons\u00e1vel por cerca de 80% do poder de focagem do olho, como a cirurgia refractiva a laser demonstrou com grande sucesso, as altera\u00e7\u00f5es na forma da c\u00f3rnea podem corrigir erros refractivos. Em olhos n\u00e3o queratoc\u00f3nicos, o cross-linking personalizado foi avaliado para a corre\u00e7\u00e3o de pequenos erros refractivos, tendo sido observada uma redu\u00e7\u00e3o m\u00e9dia de &lt;1 D na hipermetropia e na miopia ap\u00f3s 1 ano de seguimento.<\/p>\n<p>A modela\u00e7\u00e3o tridimensional por an\u00e1lise de elementos finitos da c\u00f3rnea queratoc\u00f3nica indicou que existe um enfraquecimento biomec\u00e2nico diferencial do tecido da c\u00f3rnea no cone, sugerindo que os tratamentos de menor di\u00e2metro e centrados no cone devem resultar numa maior redu\u00e7\u00e3o da curvatura da c\u00f3rnea, e os estudos iniciais sugeriram que esta abordagem resulta numa \"redu\u00e7\u00e3o um pouco maior da queratometria m\u00e1xima do que com o cross-linking convencional\".<\/p>\n<h3><strong>Queratopr\u00f3tese<\/strong><\/h3>\n<p>A Queratopr\u00f3tese de Boston (Kpro) \u00e9 uma c\u00f3rnea artificial muito utilizada para tratar doen\u00e7as da c\u00f3rnea que n\u00e3o podem ser tratadas com uma queratoplastia penetrante ou um transplante de c\u00f3rnea. Consiste num enxerto de c\u00f3rnea com um orif\u00edcio central no qual \u00e9 colocada uma parte \u00f3tica artificial e fixada a uma placa de base. No entanto, o tecido do enxerto \u00e9 propenso a derretimentos da c\u00f3rnea e \u00e0 degrada\u00e7\u00e3o do tecido, e tem sido utilizada a reticula\u00e7\u00e3o para pr\u00e9-tratar o tecido portador do dador antes de ser utilizado na cirurgia Boston Kpro, a fim de tornar o tecido do dador mais resistente \u00e0 degrada\u00e7\u00e3o.<\/p>\n<figure id=\"attachment_13768\" aria-describedby=\"caption-attachment-13768\" style=\"width: 300px\" class=\"wp-caption alignleft\"><img decoding=\"async\" class=\"wp-image-13768 size-medium\" src=\"https:\/\/www.elza-institute.com\/wp-content\/uploads\/2020\/10\/Boston-Kpro-300x150-1.jpg\" alt=\"\" width=\"300\" height=\"150\" \/><figcaption id=\"caption-attachment-13768\" class=\"wp-caption-text\">Os tr\u00eas componentes principais da Queratopr\u00f3tese de Boston (Kpro): \u00f3tica, enxerto de c\u00f3rnea e placa de base. A reticula\u00e7\u00e3o do enxerto de c\u00f3rnea pode ajudar a resistir \u00e0 fus\u00e3o da c\u00f3rnea e \u00e0 degrada\u00e7\u00e3o do tecido que por vezes ocorre em implantes de Kpro<\/figcaption><\/figure>\n<p>Os tr\u00eas componentes principais da Queratopr\u00f3tese de Boston (Kpro): \u00f3tica, enxerto de c\u00f3rnea e placa de base. A reticula\u00e7\u00e3o do enxerto de c\u00f3rnea pode ajudar a resistir \u00e0 fus\u00e3o da c\u00f3rnea e \u00e0 degrada\u00e7\u00e3o do tecido que por vezes ocorre em implantes de Kpro<\/p>\n<h3><strong>Conclus\u00e3o<\/strong><\/h3>\n<p>Tal como h\u00e1 20 anos, o padr\u00e3o de ouro atual para a realiza\u00e7\u00e3o de CXL para tratar o ceratocone progressivo \u00e9 o Protocolo de Dresden - tanto dentro como fora dos EUA. No entanto, este <em>status quo<\/em> Os avan\u00e7os na nossa compreens\u00e3o da rea\u00e7\u00e3o fotoqu\u00edmica envolvida na reticula\u00e7\u00e3o podem significar que novos protocolos e regimes de tratamento podem suplantar o protocolo de Dresden. Al\u00e9m disso, o CXL tem uma lista de indica\u00e7\u00f5es em expans\u00e3o, desde o tratamento da ectasia da c\u00f3rnea \u00e0 queratite infecciosa, e novos protocolos, regimes de tratamento e indica\u00e7\u00f5es alargadas parecem estar no horizonte. Esteja atento a este espa\u00e7o.<\/p>","protected":false},"excerpt":{"rendered":"<p>Qual \u00e9 o futuro do reticulado da c\u00f3rnea (CXL)? PACK-CXL para tratar infec\u00e7\u00f5es da c\u00f3rnea sem antibi\u00f3ticos, cross-linking refrativo e melhores Kpros...<\/p>","protected":false},"author":4,"featured_media":16085,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[214,95],"tags":[148,287,294,288,100,289,295,296,104,290,291,292,293],"class_list":["post-16078","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-farhad-hafezi","category-scientific-article","tag-accelerated-cxl","tag-avedro","tag-boston","tag-customized-cxl","tag-cxl","tag-infection","tag-keratoprosthesis","tag-kpro","tag-pack-cxl","tag-photrexa","tag-photrexa-viscous","tag-riboflavin","tag-usa"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>CXL in the USA \u2013 Part 4: The Future - The ELZA Institute<\/title>\n<meta name=\"description\" content=\"What is the future of corneal cross-linking (CXL)? 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