{"id":41822,"date":"2023-12-31T11:15:00","date_gmt":"2023-12-31T11:15:00","guid":{"rendered":"https:\/\/www.elza-institute.com\/?p=41822"},"modified":"2024-07-15T09:14:28","modified_gmt":"2024-07-15T09:14:28","slug":"new-bacterial-keratitis-treatment-paper","status":"publish","type":"post","link":"https:\/\/www.elza-institute.com\/pt\/new-bacterial-keratitis-treatment-paper\/","title":{"rendered":"Avan\u00e7os no tratamento da ceratite bacteriana: Avalia\u00e7\u00e3o do PACK-CXL acelerado de alta influ\u00eancia em c\u00f3rneas porcinas ex vivo"},"content":{"rendered":"
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O Instituto ELZA tem o prazer de informar sobre a publica\u00e7\u00e3o de um importante estudo na revista, Ci\u00eancia e tecnologia translacional da vis\u00e3o<\/em><\/a>. O manuscrito analisa os antecedentes cient\u00edficos b\u00e1sicos subjacentes \u00e0s abordagens inovadoras para o tratamento da ceratite bacteriana com crom\u00f3foro fotoactivado para a reticula\u00e7\u00e3o da ceratite-c\u00f3rnea (PACK-CXL<\/a>), utilizando riboflavina\/UV-A ou rosa bengala\/verde na c\u00f3rnea ex vivo de su\u00ednos. A queratite bacteriana \u00e9 uma infe\u00e7\u00e3o ocular grave que pode levar \u00e0 perda de vis\u00e3o ou mesmo \u00e0 cegueira se n\u00e3o for tratada. Os m\u00e9todos de tratamento actuais, como os antibi\u00f3ticos, podem ser ineficazes devido \u00e0 resist\u00eancia aos antibi\u00f3ticos e podem ter efeitos secund\u00e1rios adversos. O ponto central do estudo \u00e9 explorar estrat\u00e9gias alternativas de tratamento da queratite bacteriana.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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O nosso estudo teve como objetivo investigar a efic\u00e1cia do CXL acelerado de alta flu\u00eancia utilizando riboflavina\/luz UV-A ou rosa bengala\/luz verde para tratar infec\u00e7\u00f5es por Staphylococcus aureus ou Pseudomonas aeruginosa num ex vivo<\/em> modelo de c\u00f3rnea porcina. Os nossos resultados mostraram que os protocolos PACK-CXL riboflavina\/UV-A e rosa de bengala\/verde foram eficazes na redu\u00e7\u00e3o das unidades formadoras de col\u00f3nias bacterianas (UFC) nas c\u00f3rneas infectadas. Foram tamb\u00e9m calculados os r\u00e1cios de morte bacteriana (BKRs) resultantes dos diferentes protocolos PACK-CXL em rela\u00e7\u00e3o aos controlos n\u00e3o tratados, sendo os BKRs mais elevados alcan\u00e7ados pelo PACK-CXL rosa bengala\/verde para ambas as bact\u00e9rias. Estes resultados sugerem que o PACK-CXL acelerado de alta flu\u00eancia pode ser um tratamento alternativo promissor para a queratite bacteriana.<\/p>

O nosso estudo tem implica\u00e7\u00f5es importantes para o futuro do cross-linking corneano e para o tratamento da queratite bacteriana. A utiliza\u00e7\u00e3o dos protocolos riboflavina\/UV-A ou rosa bengala\/verde PACK-CXL pode constituir uma op\u00e7\u00e3o de tratamento segura e eficaz para os doentes com queratite bacteriana, especialmente os que apresentam infec\u00e7\u00f5es resistentes aos antibi\u00f3ticos. \u00c9 necess\u00e1ria mais investiga\u00e7\u00e3o para confirmar estes resultados em ensaios cl\u00ednicos, mas o nosso estudo fornece uma base s\u00f3lida para futuras investiga\u00e7\u00f5es. Estes resultados sublinham a necessidade de mais avan\u00e7os no tratamento da queratite bacteriana, especialmente no que diz respeito \u00e0s infec\u00e7\u00f5es resistentes aos antibi\u00f3ticos, e demonstram que o PACK-CXL parece vir a constituir uma parte importante do tratamento da queratite infecciosa no futuro.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"

Um novo estudo revela como o PACK-CXL acelerado com riboflavina\/UV-A ou rosa bengala\/luz verde pode ser um tratamento eficaz para a queratite bacteriana.<\/p>","protected":false},"author":4,"featured_media":41823,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[214,555,95],"tags":[757,756,356,104,292,669],"class_list":["post-41822","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-farhad-hafezi","category-nanji-lu","category-scientific-article","tag-bacteria","tag-bacterial-infection","tag-infectious-keratitis","tag-pack-cxl","tag-riboflavin","tag-rose-bengal"],"acf":[],"yoast_head":"\nAdvancements in Bacterial Keratitis Treatment: Evaluating High-Fluence Accelerated PACK-CXL in Ex Vivo Porcine Corneas - The ELZA Institute<\/title>\n<meta name=\"description\" content=\"New study demonstrates PACK-CXL with riboflavin\/UV-A or rose bengal\/green as effective treatments for bacterial keratitis in porcine corneas\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.elza-institute.com\/pt\/new-bacterial-keratitis-treatment-paper\/\" \/>\n<meta property=\"og:locale\" content=\"pt_PT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Advancements in Bacterial Keratitis Treatment: Evaluating High-Fluence Accelerated PACK-CXL in Ex Vivo Porcine Corneas - 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