{"id":42005,"date":"2024-02-01T08:40:45","date_gmt":"2024-02-01T08:40:45","guid":{"rendered":"https:\/\/www.elza-institute.com\/?p=42005"},"modified":"2024-07-15T09:14:03","modified_gmt":"2024-07-15T09:14:03","slug":"enhancing-corneal-enzymatic-digestion-resistance-combined-crosslinking","status":"publish","type":"post","link":"https:\/\/www.elza-institute.com\/pt\/enhancing-corneal-enzymatic-digestion-resistance-combined-crosslinking\/","title":{"rendered":"Uma melhor forma de aumentar a resist\u00eancia da c\u00f3rnea \u00e0 digest\u00e3o eznim\u00e1tica?"},"content":{"rendered":"
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Uma publica\u00e7\u00e3o recente na revista Translational Vision Science & Technology, intitulada \"A combina\u00e7\u00e3o da reticula\u00e7\u00e3o da c\u00f3rnea com riboflavina\/luz UV-A e rosa bengala\/luz verde aumenta a resist\u00eancia da digest\u00e3o enzim\u00e1tica da c\u00f3rnea<\/a>\" do Instituto ELZA, M. Enes Aydemir e colegas, apresenta um estudo perspicaz sobre a liga\u00e7\u00e3o cruzada da c\u00f3rnea (CXL) e como a realiza\u00e7\u00e3o de uma liga\u00e7\u00e3o cruzada sequencial da c\u00f3rnea com protocolos de riboflavina\/UV e rosa de bengala\/luz verde pode aumentar a resist\u00eancia da c\u00f3rnea \u00e0 digest\u00e3o enzim\u00e1tica mais do que cada protocolo isoladamente.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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O objetivo do estudo era avaliar se a aplica\u00e7\u00e3o simult\u00e2nea de riboflavina\/luz UV-A (RF\/UV-A) e rosa bengala\/luz verde (RB\/verde) no PACK-CXL epi-off poderia aumentar a resist\u00eancia da c\u00f3rnea \u00e0 digest\u00e3o enzim\u00e1tica, em compara\u00e7\u00e3o com tratamentos separados de crom\u00f3foro\/luz. Realizado em ex vivo<\/i> Para a an\u00e1lise das c\u00f3rneas de su\u00ednos, a experi\u00eancia foi metodicamente estruturada em tr\u00eas grupos, cada um sujeito a diferentes graus de tratamentos RF e RB, com e sem exposi\u00e7\u00e3o \u00e0 luz. Os resultados indicaram que as c\u00f3rneas tratadas com a metodologia combinada RF\/UV-A e RB\/verde apresentaram um aumento not\u00e1vel da resist\u00eancia \u00e0 digest\u00e3o enzim\u00e1tica do que as tratadas separadamente.<\/p>\n

Os resultados deste estudo s\u00e3o particularmente relevantes no contexto da queratite infecciosa (IK), uma causa significativa de cegueira a n\u00edvel mundial. A resist\u00eancia acrescida \u00e0 digest\u00e3o enzim\u00e1tica observada na abordagem de tratamento combinado sugere um potencial para melhorar a efic\u00e1cia do tratamento da QI, especialmente nos casos em que as terapias tradicionais s\u00e3o menos eficazes. O estudo postula que este aumento da durabilidade da c\u00f3rnea pode levar a \u00falceras de menor dimens\u00e3o em cen\u00e1rios cl\u00ednicos, o que \u00e9 crucial para a recupera\u00e7\u00e3o do doente.<\/p>\n

Al\u00e9m disso, a investiga\u00e7\u00e3o sublinha o potencial impacto translacional desta abordagem combinada de CXL. O estudo sugere que este m\u00e9todo pode refor\u00e7ar notavelmente a resist\u00eancia da c\u00f3rnea contra a digest\u00e3o da colagenase, um fator-chave na progress\u00e3o do IK. Este conhecimento do efeito sin\u00e9rgico da RF\/UV-A e da RB\/luz verde no CXL fornece uma perspetiva valiosa para futuras estrat\u00e9gias terap\u00eauticas em doen\u00e7as da c\u00f3rnea, especialmente face ao aumento da resist\u00eancia antimicrobiana.<\/p>\n

Em resumo, a investiga\u00e7\u00e3o de Aydemir et al. oferece uma contribui\u00e7\u00e3o significativa para o campo da oftalmologia, particularmente na \u00e1rea do tratamento de doen\u00e7as da c\u00f3rnea. A abordagem combinada de RF\/UV-A e RB\/luz verde no PACK-CXL apresenta uma dire\u00e7\u00e3o promissora para investiga\u00e7\u00e3o futura e aplica\u00e7\u00e3o cl\u00ednica, melhorando potencialmente a gest\u00e3o e os resultados da queratite infecciosa.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Imagem representativa de uma placa de 24 po\u00e7os contendo c\u00f3rneas imediatamente ap\u00f3s imers\u00e3o em solu\u00e7\u00e3o de colagenase 0,3% (A) e ap\u00f3s 25 horas (B) de digest\u00e3o em solu\u00e7\u00e3o de colagenase A 0,3%, e no ponto final (C).<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"

Uma publica\u00e7\u00e3o recente na TVST por M. Enes Aydemir et al. da ELZA apresenta um estudo perspicaz sobre a forma como a realiza\u00e7\u00e3o de reticula\u00e7\u00e3o sequencial da c\u00f3rnea com protocolos de riboflavina\/UV e rosa de bengala\/luz verde pode aumentar a resist\u00eancia \u00e0 digest\u00e3o da c\u00f3rnea mais do que cada protocolo isoladamente.<\/p>","protected":false},"author":4,"featured_media":42035,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[770,95],"tags":[209,130,100,690,669,687,122],"class_list":["post-42005","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-enes-aydemir","category-scientific-article","tag-basic-research","tag-cross-linking","tag-cxl","tag-green-light","tag-rose-bengal","tag-rose-bengal-green-light","tag-translational-research"],"acf":[],"yoast_head":"\nA better way of enhancing corneal eznymatic digestion 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