{"id":50576,"date":"2025-07-10T09:28:09","date_gmt":"2025-07-10T09:28:09","guid":{"rendered":"https:\/\/www.elza-institute.com\/?p=46010"},"modified":"2025-07-10T09:28:10","modified_gmt":"2025-07-10T09:28:10","slug":"new-transepithelial-corneal-cross-linking-protocol-matches-epi-off-biomechanics","status":"publish","type":"post","link":"https:\/\/www.elza-institute.com\/pt\/new-transepithelial-corneal-cross-linking-protocol-matches-epi-off-biomechanics\/","title":{"rendered":"O novo protocolo de reticula\u00e7\u00e3o transepitelial da c\u00f3rnea corresponde \u00e0 biomec\u00e2nica do Epi-Off"},"content":{"rendered":"
\n\t\t\t\t
\n\t\t
\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\"\"\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t

O cross-linking da c\u00f3rnea (CXL) continua a ser a \u00fanica interven\u00e7\u00e3o que comprovadamente interrompe a progress\u00e3o do ceratocone. Embora o protocolo original de Dresden tenha estabelecido a efic\u00e1cia do CXL sem epit\u00e9lio (epi-off), a dor associada, o atraso na cicatriza\u00e7\u00e3o e o risco de infe\u00e7\u00e3o motivaram durante muito tempo as tentativas de desenvolver alternativas eficazes de epit\u00e9lio com epit\u00e9lio (epi-on). No entanto, a obten\u00e7\u00e3o de resultados biomec\u00e2nicos equivalentes com um epit\u00e9lio intacto - cross-linking corneano transepitelial - tem-se revelado tecnicamente dif\u00edcil devido \u00e0s barreiras na penetra\u00e7\u00e3o da riboflavina e na difus\u00e3o do oxig\u00e9nio.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

\n\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t

Num estudo ex vivo recentemente publicado, o nosso grupo avaliou sistematicamente um protocolo de reticula\u00e7\u00e3o corneana transepitelial recentemente desenvolvido. Utilizando c\u00f3rneas porcinas como um modelo ex vivo validado, os autores compararam os resultados biomec\u00e2nicos entre o seu novo protocolo epi-on e o protocolo epi-off acelerado amplamente adotado (9 mW\/cm2, 10 minutos, flu\u00eancia de 5,4 J\/cm2). Este estudo foi publicado na revista Revista de Cirurgia Refractiva<\/a>.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

\n\t\t\t\t\t
\n\t\t
\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t

A chave para esta nova abordagem \u00e9 uma solu\u00e7\u00e3o potenciadora de penetra\u00e7\u00e3o de segunda gera\u00e7\u00e3o que facilita a difus\u00e3o da riboflavina atrav\u00e9s do epit\u00e9lio intacto sem induzir danos epiteliais. Al\u00e9m disso, o protocolo utiliza irradia\u00e7\u00e3o UV-A pulsada acelerada (18 mW\/cm2, 1 segundo ligado\/1 segundo desligado, durante 15 minutos; flu\u00eancia total de 8,1 J\/cm2) para otimizar a disponibilidade de oxig\u00e9nio durante o processo de reticula\u00e7\u00e3o.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\"\"\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
\n\t\t\t\t\t
\n\t\t
\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\"\"\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t

A avalia\u00e7\u00e3o biomec\u00e2nica foi efectuada atrav\u00e9s de extensometria tens\u00e3o-deforma\u00e7\u00e3o, avaliando o m\u00f3dulo de elasticidade a uma tens\u00e3o de 5-10% (que \u00e9 o intervalo padr\u00e3o para este tipo de an\u00e1lises). Os resultados n\u00e3o demonstraram qualquer diferen\u00e7a significativa entre os m\u00f3dulos el\u00e1sticos do novo protocolo epi-on e da refer\u00eancia epi-off acelerada, embora ambos fossem significativamente mais r\u00edgidos do que os controlos n\u00e3o tratados. Isto sugere que, pelo menos do ponto de vista biomec\u00e2nico, o protocolo transepitelial produz um efeito equivalente ao CXL epi-off acelerado.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

\n\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t

Com a primeira autoria de\u00a0<\/span>Dr. Nanji Lu<\/a>Este estudo tamb\u00e9m aborda cuidadosamente os desafios conhecidos do CXL epi-on. A barreira epitelial apresenta uma dupla limita\u00e7\u00e3o: a riboflavina, uma mol\u00e9cula hidrof\u00edlica, penetra mal no epit\u00e9lio intacto, enquanto o pr\u00f3prio epit\u00e9lio consome oxig\u00e9nio a taxas substancialmente superiores aos n\u00edveis do estroma. As tentativas anteriores, incluindo os intensificadores qu\u00edmicos de primeira gera\u00e7\u00e3o e a iontoforese, n\u00e3o conseguiram fornecer concentra\u00e7\u00f5es suficientes de riboflavina ou aumentaram a complexidade do procedimento sem resolver completamente estas limita\u00e7\u00f5es.<\/span><\/p>

Ao resolver as limita\u00e7\u00f5es da riboflavina e do oxig\u00e9nio atrav\u00e9s do melhoramento qu\u00edmico e da dosagem optimizada de UV-A, o protocolo descrito por Lu et al. simplifica potencialmente o CXL epi-on, transformando-o num procedimento totalmente baseado no consult\u00f3rio, que pode evitar a necessidade de um ambiente cir\u00fargico est\u00e9ril.<\/p>

No entanto, os autores reconhecem limita\u00e7\u00f5es cr\u00edticas. O modelo porcino ex vivo, embora metodologicamente robusto, n\u00e3o pode reproduzir totalmente as respostas in vivo, como a cicatriza\u00e7\u00e3o de feridas e a remodela\u00e7\u00e3o dos querat\u00f3citos. Al\u00e9m disso, as diferen\u00e7as anat\u00f3micas (em particular, o epit\u00e9lio porcino mais espesso e a aus\u00eancia da camada de Bowman) requerem uma an\u00e1lise cuidadosa quando se extrapolam os resultados para a pr\u00e1tica cl\u00ednica.<\/p>

Embora estes resultados forne\u00e7am provas biomec\u00e2nicas convincentes, a valida\u00e7\u00e3o cl\u00ednica continua a ser essencial. Est\u00e1 atualmente em curso um ensaio cl\u00ednico para avaliar a seguran\u00e7a e a efic\u00e1cia a longo prazo. Se os dados cl\u00ednicos subsequentes confirmarem estes resultados ex vivo, esta abordagem de reticula\u00e7\u00e3o transepitelial poder\u00e1 marcar um avan\u00e7o significativo no tratamento do ceratocone, reduzindo a carga do doente sem comprometer a efic\u00e1cia biomec\u00e2nica.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

\n\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t

Refer\u00eancia:<\/strong>
Lu NJ, Torres-Netto EA, Aydemir EA, et al. Um protocolo de reticula\u00e7\u00e3o transepitelial da c\u00f3rnea (CXL) que proporciona o mesmo refor\u00e7o biomec\u00e2nico que o CXL acelerado sem epit\u00e9lio. J Refract Surg<\/em>. 2025 ePub ahead of print. doi:10.3928\/1081597X-20250515-09<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"

O reticulado corneano transepitelial oferece um novo protocolo CXL epi-on com resultados biomec\u00e2nicos compar\u00e1veis ao CXL epi-off acelerado para o tratamento do ceratocone<\/p>","protected":false},"author":4,"featured_media":46013,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[555,95],"tags":[1257,275,637,975,1258,1259,1260,1261],"class_list":["post-50576","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-nanji-lu","category-scientific-article","tag-accelerated-cxl-protoco","tag-corneal-biomechanics","tag-epi-on-cxl","tag-keratoconus-treatment","tag-oxygen-diffusion","tag-riboflavin-penetration","tag-transepithelial-corneal-cross-linking","tag-uv-a-cross-linking"],"acf":[],"yoast_head":"\nNew Transepithelial Corneal Cross-Linking Protocol Matches Epi-Off Biomechanics - The ELZA Institute<\/title>\n<meta name=\"description\" content=\"New transepithelial corneal cross-linking protocol shows biomechanical equivalence to accelerated epi-off CXL in porcine ex vivo study.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.elza-institute.com\/pt\/new-transepithelial-corneal-cross-linking-protocol-matches-epi-off-biomechanics\/\" \/>\n<meta property=\"og:locale\" content=\"pt_PT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"New Transepithelial Corneal Cross-Linking Protocol Matches Epi-Off Biomechanics - The ELZA Institute\" \/>\n<meta property=\"og:description\" content=\"New transepithelial corneal cross-linking protocol shows biomechanical equivalence to accelerated epi-off CXL in porcine ex vivo study.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.elza-institute.com\/pt\/new-transepithelial-corneal-cross-linking-protocol-matches-epi-off-biomechanics\/\" \/>\n<meta property=\"og:site_name\" content=\"The ELZA Institute\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/ELZA.Institute\/\" \/>\n<meta property=\"article:published_time\" content=\"2025-07-10T09:28:09+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-07-10T09:28:10+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.elza-institute.com\/wp-content\/uploads\/2025\/06\/New-Transepithelial-Cross-Linking-Protocol-Matches-Epi-Off-Biomechanics.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1200\" \/>\n\t<meta property=\"og:image:height\" content=\"600\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Mark Hillen\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"Mark Hillen\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tempo estimado de leitura\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutos\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.elza-institute.com\/new-transepithelial-corneal-cross-linking-protocol-matches-epi-off-biomechanics\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.elza-institute.com\/new-transepithelial-corneal-cross-linking-protocol-matches-epi-off-biomechanics\/\"},\"author\":{\"name\":\"Mark Hillen\",\"@id\":\"https:\/\/www.elza-institute.com\/#\/schema\/person\/e3929262886a5a60dd6965a6bc721d15\"},\"headline\":\"New Transepithelial Corneal Cross-Linking Protocol Matches Epi-Off Biomechanics\",\"datePublished\":\"2025-07-10T09:28:09+00:00\",\"dateModified\":\"2025-07-10T09:28:10+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.elza-institute.com\/new-transepithelial-corneal-cross-linking-protocol-matches-epi-off-biomechanics\/\"},\"wordCount\":498,\"publisher\":{\"@id\":\"https:\/\/www.elza-institute.com\/#organization\"},\"image\":{\"@id\":\"https:\/\/www.elza-institute.com\/new-transepithelial-corneal-cross-linking-protocol-matches-epi-off-biomechanics\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.elza-institute.com\/wp-content\/uploads\/2025\/06\/New-Transepithelial-Cross-Linking-Protocol-Matches-Epi-Off-Biomechanics.jpg\",\"keywords\":[\"accelerated CXL protoco\",\"corneal biomechanics\",\"Epi-on CXL\",\"keratoconus treatment\",\"oxygen diffusion\",\"riboflavin penetration\",\"transepithelial corneal cross-linking\",\"UV-A cross-linking\"],\"articleSection\":[\"Nanji Lu\",\"Scientific article\"],\"inLanguage\":\"pt-PT\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.elza-institute.com\/new-transepithelial-corneal-cross-linking-protocol-matches-epi-off-biomechanics\/\",\"url\":\"https:\/\/www.elza-institute.com\/new-transepithelial-corneal-cross-linking-protocol-matches-epi-off-biomechanics\/\",\"name\":\"New Transepithelial Corneal Cross-Linking Protocol Matches Epi-Off Biomechanics - The ELZA Institute\",\"isPartOf\":{\"@id\":\"https:\/\/www.elza-institute.com\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.elza-institute.com\/new-transepithelial-corneal-cross-linking-protocol-matches-epi-off-biomechanics\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.elza-institute.com\/new-transepithelial-corneal-cross-linking-protocol-matches-epi-off-biomechanics\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.elza-institute.com\/wp-content\/uploads\/2025\/06\/New-Transepithelial-Cross-Linking-Protocol-Matches-Epi-Off-Biomechanics.jpg\",\"datePublished\":\"2025-07-10T09:28:09+00:00\",\"dateModified\":\"2025-07-10T09:28:10+00:00\",\"description\":\"New transepithelial corneal cross-linking protocol shows biomechanical equivalence to accelerated epi-off CXL in porcine ex vivo study.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.elza-institute.com\/new-transepithelial-corneal-cross-linking-protocol-matches-epi-off-biomechanics\/#breadcrumb\"},\"inLanguage\":\"pt-PT\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.elza-institute.com\/new-transepithelial-corneal-cross-linking-protocol-matches-epi-off-biomechanics\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"pt-PT\",\"@id\":\"https:\/\/www.elza-institute.com\/new-transepithelial-corneal-cross-linking-protocol-matches-epi-off-biomechanics\/#primaryimage\",\"url\":\"https:\/\/www.elza-institute.com\/wp-content\/uploads\/2025\/06\/New-Transepithelial-Cross-Linking-Protocol-Matches-Epi-Off-Biomechanics.jpg\",\"contentUrl\":\"https:\/\/www.elza-institute.com\/wp-content\/uploads\/2025\/06\/New-Transepithelial-Cross-Linking-Protocol-Matches-Epi-Off-Biomechanics.jpg\",\"width\":1200,\"height\":600},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.elza-institute.com\/new-transepithelial-corneal-cross-linking-protocol-matches-epi-off-biomechanics\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.elza-institute.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Nanji Lu\",\"item\":\"https:\/\/www.elza-institute.com\/nanji-lu\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"New Transepithelial Corneal Cross-Linking Protocol Matches Epi-Off Biomechanics\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.elza-institute.com\/#website\",\"url\":\"https:\/\/www.elza-institute.com\/\",\"name\":\"The ELZA Institute\",\"description\":\"Swiss EyeCare at its finest\",\"publisher\":{\"@id\":\"https:\/\/www.elza-institute.com\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.elza-institute.com\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"pt-PT\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.elza-institute.com\/#organization\",\"name\":\"The ELZA Institute\",\"url\":\"https:\/\/www.elza-institute.com\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"pt-PT\",\"@id\":\"https:\/\/www.elza-institute.com\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.elza-institute.com\/wp-content\/uploads\/2016\/04\/ELZA-logo-V4.jpg\",\"contentUrl\":\"https:\/\/www.elza-institute.com\/wp-content\/uploads\/2016\/04\/ELZA-logo-V4.jpg\",\"width\":1181,\"height\":453,\"caption\":\"The ELZA Institute\"},\"image\":{\"@id\":\"https:\/\/www.elza-institute.com\/#\/schema\/logo\/image\/\"},\"sameAs\":[\"https:\/\/www.facebook.com\/ELZA.Institute\/\",\"https:\/\/x.com\/ELZA_Institute\",\"https:\/\/www.linkedin.com\/company\/elza-institute?trk=top_nav_home\"]},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.elza-institute.com\/#\/schema\/person\/e3929262886a5a60dd6965a6bc721d15\",\"name\":\"Mark Hillen\",\"url\":\"https:\/\/www.elza-institute.com\/pt\/author\/markhillen\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"O novo protocolo de reticula\u00e7\u00e3o transepitelial da c\u00f3rnea corresponde \u00e0 biomec\u00e2nica do Epi-Off - The ELZA Institute","description":"Novo protocolo de reticula\u00e7\u00e3o transepitelial da c\u00f3rnea mostra equival\u00eancia biomec\u00e2nica ao CXL epi-off acelerado num estudo ex vivo em su\u00ednos.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.elza-institute.com\/pt\/new-transepithelial-corneal-cross-linking-protocol-matches-epi-off-biomechanics\/","og_locale":"pt_PT","og_type":"article","og_title":"New Transepithelial Corneal Cross-Linking Protocol Matches Epi-Off Biomechanics - The ELZA Institute","og_description":"New transepithelial corneal cross-linking protocol shows biomechanical equivalence to accelerated epi-off CXL in porcine ex vivo study.","og_url":"https:\/\/www.elza-institute.com\/pt\/new-transepithelial-corneal-cross-linking-protocol-matches-epi-off-biomechanics\/","og_site_name":"The ELZA Institute","article_publisher":"https:\/\/www.facebook.com\/ELZA.Institute\/","article_published_time":"2025-07-10T09:28:09+00:00","article_modified_time":"2025-07-10T09:28:10+00:00","og_image":[{"width":1200,"height":600,"url":"https:\/\/www.elza-institute.com\/wp-content\/uploads\/2025\/06\/New-Transepithelial-Cross-Linking-Protocol-Matches-Epi-Off-Biomechanics.jpg","type":"image\/jpeg"}],"author":"Mark Hillen","twitter_misc":{"Escrito por":"Mark Hillen","Tempo estimado de leitura":"3 minutos"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.elza-institute.com\/new-transepithelial-corneal-cross-linking-protocol-matches-epi-off-biomechanics\/#article","isPartOf":{"@id":"https:\/\/www.elza-institute.com\/new-transepithelial-corneal-cross-linking-protocol-matches-epi-off-biomechanics\/"},"author":{"name":"Mark Hillen","@id":"https:\/\/www.elza-institute.com\/#\/schema\/person\/e3929262886a5a60dd6965a6bc721d15"},"headline":"New Transepithelial Corneal Cross-Linking Protocol Matches Epi-Off Biomechanics","datePublished":"2025-07-10T09:28:09+00:00","dateModified":"2025-07-10T09:28:10+00:00","mainEntityOfPage":{"@id":"https:\/\/www.elza-institute.com\/new-transepithelial-corneal-cross-linking-protocol-matches-epi-off-biomechanics\/"},"wordCount":498,"publisher":{"@id":"https:\/\/www.elza-institute.com\/#organization"},"image":{"@id":"https:\/\/www.elza-institute.com\/new-transepithelial-corneal-cross-linking-protocol-matches-epi-off-biomechanics\/#primaryimage"},"thumbnailUrl":"https:\/\/www.elza-institute.com\/wp-content\/uploads\/2025\/06\/New-Transepithelial-Cross-Linking-Protocol-Matches-Epi-Off-Biomechanics.jpg","keywords":["accelerated CXL protoco","corneal biomechanics","Epi-on CXL","keratoconus treatment","oxygen diffusion","riboflavin penetration","transepithelial corneal cross-linking","UV-A cross-linking"],"articleSection":["Nanji Lu","Scientific article"],"inLanguage":"pt-PT"},{"@type":"WebPage","@id":"https:\/\/www.elza-institute.com\/new-transepithelial-corneal-cross-linking-protocol-matches-epi-off-biomechanics\/","url":"https:\/\/www.elza-institute.com\/new-transepithelial-corneal-cross-linking-protocol-matches-epi-off-biomechanics\/","name":"O novo protocolo de reticula\u00e7\u00e3o transepitelial da c\u00f3rnea corresponde \u00e0 biomec\u00e2nica do Epi-Off - The ELZA Institute","isPartOf":{"@id":"https:\/\/www.elza-institute.com\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.elza-institute.com\/new-transepithelial-corneal-cross-linking-protocol-matches-epi-off-biomechanics\/#primaryimage"},"image":{"@id":"https:\/\/www.elza-institute.com\/new-transepithelial-corneal-cross-linking-protocol-matches-epi-off-biomechanics\/#primaryimage"},"thumbnailUrl":"https:\/\/www.elza-institute.com\/wp-content\/uploads\/2025\/06\/New-Transepithelial-Cross-Linking-Protocol-Matches-Epi-Off-Biomechanics.jpg","datePublished":"2025-07-10T09:28:09+00:00","dateModified":"2025-07-10T09:28:10+00:00","description":"Novo protocolo de reticula\u00e7\u00e3o transepitelial da c\u00f3rnea mostra equival\u00eancia biomec\u00e2nica ao CXL epi-off acelerado num estudo ex vivo em su\u00ednos.","breadcrumb":{"@id":"https:\/\/www.elza-institute.com\/new-transepithelial-corneal-cross-linking-protocol-matches-epi-off-biomechanics\/#breadcrumb"},"inLanguage":"pt-PT","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.elza-institute.com\/new-transepithelial-corneal-cross-linking-protocol-matches-epi-off-biomechanics\/"]}]},{"@type":"ImageObject","inLanguage":"pt-PT","@id":"https:\/\/www.elza-institute.com\/new-transepithelial-corneal-cross-linking-protocol-matches-epi-off-biomechanics\/#primaryimage","url":"https:\/\/www.elza-institute.com\/wp-content\/uploads\/2025\/06\/New-Transepithelial-Cross-Linking-Protocol-Matches-Epi-Off-Biomechanics.jpg","contentUrl":"https:\/\/www.elza-institute.com\/wp-content\/uploads\/2025\/06\/New-Transepithelial-Cross-Linking-Protocol-Matches-Epi-Off-Biomechanics.jpg","width":1200,"height":600},{"@type":"BreadcrumbList","@id":"https:\/\/www.elza-institute.com\/new-transepithelial-corneal-cross-linking-protocol-matches-epi-off-biomechanics\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.elza-institute.com\/"},{"@type":"ListItem","position":2,"name":"Nanji Lu","item":"https:\/\/www.elza-institute.com\/nanji-lu\/"},{"@type":"ListItem","position":3,"name":"New Transepithelial Corneal Cross-Linking Protocol Matches Epi-Off Biomechanics"}]},{"@type":"WebSite","@id":"https:\/\/www.elza-institute.com\/#website","url":"https:\/\/www.elza-institute.com\/","name":"O Instituto ELZA","description":"Swiss EyeCare no seu melhor","publisher":{"@id":"https:\/\/www.elza-institute.com\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.elza-institute.com\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"pt-PT"},{"@type":"Organization","@id":"https:\/\/www.elza-institute.com\/#organization","name":"O Instituto ELZA","url":"https:\/\/www.elza-institute.com\/","logo":{"@type":"ImageObject","inLanguage":"pt-PT","@id":"https:\/\/www.elza-institute.com\/#\/schema\/logo\/image\/","url":"https:\/\/www.elza-institute.com\/wp-content\/uploads\/2016\/04\/ELZA-logo-V4.jpg","contentUrl":"https:\/\/www.elza-institute.com\/wp-content\/uploads\/2016\/04\/ELZA-logo-V4.jpg","width":1181,"height":453,"caption":"The ELZA Institute"},"image":{"@id":"https:\/\/www.elza-institute.com\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/ELZA.Institute\/","https:\/\/x.com\/ELZA_Institute","https:\/\/www.linkedin.com\/company\/elza-institute?trk=top_nav_home"]},{"@type":"Person","@id":"https:\/\/www.elza-institute.com\/#\/schema\/person\/e3929262886a5a60dd6965a6bc721d15","name":"Mark Hillen","url":"https:\/\/www.elza-institute.com\/pt\/author\/markhillen\/"}]}},"_links":{"self":[{"href":"https:\/\/www.elza-institute.com\/pt\/wp-json\/wp\/v2\/posts\/50576","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.elza-institute.com\/pt\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.elza-institute.com\/pt\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.elza-institute.com\/pt\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/www.elza-institute.com\/pt\/wp-json\/wp\/v2\/comments?post=50576"}],"version-history":[{"count":0,"href":"https:\/\/www.elza-institute.com\/pt\/wp-json\/wp\/v2\/posts\/50576\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.elza-institute.com\/pt\/wp-json\/wp\/v2\/media\/46013"}],"wp:attachment":[{"href":"https:\/\/www.elza-institute.com\/pt\/wp-json\/wp\/v2\/media?parent=50576"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.elza-institute.com\/pt\/wp-json\/wp\/v2\/categories?post=50576"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.elza-institute.com\/pt\/wp-json\/wp\/v2\/tags?post=50576"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}