{"id":50790,"date":"2025-08-13T12:41:57","date_gmt":"2025-08-13T12:41:57","guid":{"rendered":"https:\/\/www.elza-institute.com\/?p=50790"},"modified":"2025-11-10T11:03:59","modified_gmt":"2025-11-10T11:03:59","slug":"human-lens-oct-mapping-refractive-index-and-strain-in-action","status":"publish","type":"post","link":"https:\/\/www.elza-institute.com\/pt\/human-lens-oct-mapping-refractive-index-and-strain-in-action\/","title":{"rendered":"OCT do cristalino humano: mapeamento do \u00edndice de refra\u00e7\u00e3o e da deforma\u00e7\u00e3o em a\u00e7\u00e3o"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"50790\" class=\"elementor elementor-50790\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-68ccbd5d e-flex e-con-boxed e-con e-parent\" data-id=\"68ccbd5d\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5c8dd0b7 elementor-widget elementor-widget-text-editor\" data-id=\"5c8dd0b7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><\/p>\n<p>The human crystalline lens is an optical marvel that adjusts focus through <span data-start=\"75\" data-end=\"92\">accommodation<\/span>, changing shape to shift focus. With age, this flexibility diminishes, leading to presbyopia. Understanding both how the lens deforms and how its optical properties shift is essential for advancing diagnostics and therapeutic design. A new <span data-start=\"334\" data-end=\"352\">human lens OCT<\/span> study offers this insight by using optical coherence tomography to simultaneously map lens optics and mechanics.<\/p>\n<p>\u00a0<\/p>\n<p>A recent study by <a style=\"background-color: #ffffff;\" href=\"https:\/\/www.linkedin.com\/in\/sabine-kling-7b252648\/\">Sabine Kling<\/a>, <a style=\"background-color: #ffffff;\" href=\"https:\/\/www.linkedin.com\/in\/vahoura-tahsini-449516151\/\">Vahoura Tahsini<\/a>, and <a style=\"background-color: #ffffff;\" href=\"https:\/\/www.elza-institute.com\/about-elza-2\/farhad-hafezi\/\">Farhad Hafezi<\/a>, published in <em><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0014483525001034\">Experimental Eye Research<\/a><\/em>, introduces a breakthrough human lens OCT approach. Using high-resolution optical coherence tomography (OCT) and advanced phase-based signal processing, the team was able to map \u2013 simultaneously and in real time \u2013 both the gradient refractive index and the mechanical strain within the human lens under accommodative stress.<\/p>\n<p>\u00a0<\/p>\n<p><\/p>\n<p><\/p>\n<h3 class=\"wp-block-heading\"><b>Human lens OCT study design<\/b><\/h3>\n<div>\n<p data-start=\"335\" data-end=\"372\">Six healthy adults (24\u201345 years) underwent OCT imaging under three accommodative demands: none, \u20132\u202fdiopters, and \u20134\u202fdiopters. Advanced signal-processing enabled pixel-level mapping of refractive index, while real-time micro\u2011fluctuation analysis yielded measures of:<\/p>\n<ul data-start=\"374\" data-end=\"455\">\n<li data-start=\"374\" data-end=\"415\">\n<p data-start=\"376\" data-end=\"415\"><span data-start=\"0\" data-end=\"24\" data-is-only-node=\"\">Instantaneous strain<\/span> (rate of deformation)<\/p>\n<\/li>\n<li data-start=\"416\" data-end=\"455\">\n<p data-start=\"418\" data-end=\"455\"><span data-start=\"0\" data-end=\"22\" data-is-only-node=\"\">Accumulated strain<\/span> (total deformation over time)<\/p>\n<\/li>\n<\/ul>\n<p data-start=\"457\" data-end=\"494\">This dual mapping extends Dr\u202fTahsini\u2019s earlier OCE-based investigations into lens mechanics by adding simultaneous optical mapping to the biomechanical profiling portfolio.<\/p>\n<p data-start=\"457\" data-end=\"494\">\u00a0<\/p>\n<\/div>\n<p><\/p>\n<p><\/p>\n<h3 class=\"wp-block-heading\"><strong>Key findings<\/strong><\/h3>\n<p><\/p>\n<p><\/p>\n<ul class=\"wp-block-list\">\n<li style=\"list-style-type: none;\">\n<ul><\/ul>\n<\/li>\n<\/ul>\n<ul>\n<li style=\"list-style-type: none;\">\n<ul>\n<li data-start=\"544\" data-end=\"585\">\n<p data-start=\"546\" data-end=\"585\">A pronounced <span data-start=\"13\" data-end=\"48\">axial gradient refractive index<\/span>, with highest values in the posterior lens.<\/p>\n<\/li>\n<li data-start=\"586\" data-end=\"629\">\n<p data-start=\"588\" data-end=\"629\">Refractive index proved stable across age and accommodative states in participants under 45.<\/p>\n<\/li>\n<li data-start=\"630\" data-end=\"673\">\n<p data-start=\"632\" data-end=\"673\"><span data-start=\"0\" data-end=\"24\" data-is-only-node=\"\">Instantaneous strain<\/span> decreased with age, indicating slower deformation in older lenses.<\/p>\n<\/li>\n<li data-start=\"674\" data-end=\"717\">\n<p data-start=\"676\" data-end=\"717\"><span data-start=\"0\" data-end=\"22\" data-is-only-node=\"\">Accumulated strain<\/span> rose with increasing accommodative demand.<\/p>\n<\/li>\n<li data-start=\"718\" data-end=\"759\">\n<p data-start=\"720\" data-end=\"759\">No direct spatial correlation was observed between refractive index distribution and mechanical strain.<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p><\/p>\n<p><\/p>\n<p><\/p>\n<h3 class=\"wp-block-heading\"><strong>Why human lens OCT matters<\/strong><\/h3>\n<p><\/p>\n<p><\/p>\n<p>This technique provides <span data-start=\"24\" data-end=\"49\">patient-specific maps<\/span> of both optical and mechanical lens behavior, complementing this research group&#8217;s viscoelastic estimations of the lens and the infrastructure of SSI-based corneal stiffness mapping. Together, these methods deepen understanding of ocular tissue function with age and refractive state.<\/p>\n<p data-start=\"987\" data-end=\"1020\">Potential applications include:<\/p>\n<ul data-start=\"1021\" data-end=\"1156\">\n<li data-start=\"1021\" data-end=\"1057\">\n<p data-start=\"1023\" data-end=\"1057\">Early diagnostics for presbyopia<\/p>\n<\/li>\n<li data-start=\"1058\" data-end=\"1104\">\n<p data-start=\"1060\" data-end=\"1104\">Personalized refractive treatment planning<\/p>\n<\/li>\n<li data-start=\"1105\" data-end=\"1156\">\n<p data-start=\"1107\" data-end=\"1156\">Modeling emmetropization and myopization dynamics<\/p>\n<\/li>\n<\/ul>\n<p data-start=\"1158\" data-end=\"1329\">By integrating OCT with biomechanical analysis, <span data-start=\"1206\" data-end=\"1224\">human lens OCT<\/span> emerges as a translational tool for vision science, bridging optics and mechanics in a clinical context.<\/p>\n<p><\/p>\n<p><\/p>\n<p><\/p>\n<p><\/p>\n<p><b>Reference<\/b><br \/>Kling S, Tahsini V, Hafezi F. Dynamic in vivo mapping of the gradient refractive index and strain distribution of the human lens under accommodative stress. <i>Experimental Eye Research<\/i>. 2025;255:110332. [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40081752\/\">PubMed<\/a>]<\/p>\n<p><\/p>\n<p><\/p>\n<p><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>A OCT do cristalino humano mapeia o \u00edndice de refra\u00e7\u00e3o e a tens\u00e3o, oferecendo novas perspectivas sobre a acomoda\u00e7\u00e3o, o envelhecimento e a biomec\u00e2nica ocular.<\/p>","protected":false},"author":4,"featured_media":50796,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[1433,1439,1440,1443,963,1436,1434,1431,1445,1438,1444,965,1432,1446,1442,1441,1437,1435,1447,1448],"class_list":["post-50790","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-general-news","tag-accommodative-strain","tag-accumulated-strain","tag-age-related-lens-deformation","tag-emmetropization-dynamics","tag-gradient-refractive-index","tag-high-resolution-oct-imaging","tag-human-crystalline-lens","tag-human-lens-oct","tag-human-lens-optical-mapping","tag-instantaneous-strain","tag-laser-eye-optics-and-mechanics","tag-lens-biomechanics","tag-lens-mechanics","tag-lens-strain-distribution","tag-myopization-modelling","tag-personalized-refractive-treatment-planning","tag-phase-based-signal-processing","tag-presbyopia-diagnostics","tag-refractive-index-stability","tag-translational-vision-science"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - 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