{"id":51989,"date":"2025-05-16T11:39:21","date_gmt":"2025-05-16T11:39:21","guid":{"rendered":"https:\/\/www.elza-institute.com\/?p=51989"},"modified":"2026-02-03T11:43:55","modified_gmt":"2026-02-03T11:43:55","slug":"eco-cairs-osn","status":"publish","type":"post","link":"https:\/\/www.elza-institute.com\/pt\/eco-cairs-osn\/","title":{"rendered":"ECO-CAIRS e a evolu\u00e7\u00e3o da cirurgia aditiva do ceratocone"},"content":{"rendered":"
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Cobertura recente em Healio<\/a><\/em> destaca o crescente interesse cl\u00ednico nos segmentos de anel intrastromal alog\u00e9nico da c\u00f3rnea (CAIRS) como uma alternativa baseada em tecido aos segmentos de anel sint\u00e9ticos para o ceratocone e a ectasia da c\u00f3rnea. Dentro deste campo em evolu\u00e7\u00e3o, Farhad Hafezi, MD, PhD, FARVO<\/a><\/span>, Diretor M\u00e9dico do Instituto ELZA, contribuiu com uma perspetiva biomec\u00e2nica e translacional distinta atrav\u00e9s do desenvolvimento de ECO-CAIRS<\/a><\/span> (Extracorporeal Optimization of Corneal Allogenic Intrastromal Ring Segments).<\/p>

As CAIRS foram originalmente introduzidas como uma abordagem lamelar aditiva de meio estromal, concebida para regularizar a c\u00f3rnea sem induzir as concentra\u00e7\u00f5es de tens\u00e3o associadas aos segmentos de anel de PMMA. Conforme discutido no Healio<\/em> Segundo o relat\u00f3rio, a utiliza\u00e7\u00e3o de tecido de dador humano permite uma intera\u00e7\u00e3o mais fisiol\u00f3gica com a c\u00f3rnea hospedeira, reduzindo riscos como a extrus\u00e3o, a migra\u00e7\u00e3o e a fus\u00e3o do estroma.<\/p>

Com base nestes fundamentos, o Prof. Hafezi apresentou o ECO-CAIRS como uma estrat\u00e9gia para melhorar o manuseamento, a esterilidade e a previsibilidade biomec\u00e2nica dos segmentos alog\u00e9nicos. Em vez de se basear apenas na desidrata\u00e7\u00e3o prolongada ou no aumento da rigidez, o ECO-CAIRS aplica reticula\u00e7\u00e3o extracorporal da c\u00f3rnea<\/span> ao tecido do dador antes da implanta\u00e7\u00e3o. Ao utilizar um nomograma dedicado de reticula\u00e7\u00e3o de alta flu\u00eancia fora do olho humano, o tecido \u00e9 endurecido, esterilizado e torna-se mais f\u00e1cil de implantar - sem expor a c\u00f3rnea ou o endot\u00e9lio do doente a riscos adicionais.<\/p>

Uma das principais vantagens desta abordagem \u00e9 que os segmentos alog\u00e9nicos reticulados n\u00e3o incham durante a implanta\u00e7\u00e3o, mas reidratam gradualmente no p\u00f3s-operat\u00f3rio. Hafezi e os seus colegas demonstraram que este \u00e9 o principal fator determinante do efeito de aplanamento da c\u00f3rnea. Os estudos de elastografia OCT realizados no ELZA demonstraram ainda que os segmentos baseados em tecido se comportam biomecanicamente mais perto da c\u00f3rnea nativa do que os an\u00e9is sint\u00e9ticos, evitando os padr\u00f5es de tens\u00e3o n\u00e3o fisiol\u00f3gicos observados com o PMMA.<\/p>

Na pr\u00e1tica cl\u00ednica, o ECO-CAIRS n\u00e3o \u00e9 visto como uma solu\u00e7\u00e3o aut\u00f3noma, mas sim como parte de um estrat\u00e9gia modular e individualizada para o ceratocone<\/span>. No Instituto ELZA, o ECO-CAIRS pode ser combinado com o cross-linking da c\u00f3rnea - simult\u00e2nea ou sequencialmente - e, em casos selecionados, com protocolos personalizados, tais como ELZA-PACE<\/span>, onde a modula\u00e7\u00e3o epitelial guiada por mapa \u00e9 utilizada para melhorar os efeitos de reticula\u00e7\u00e3o sobre o cone.<\/p>

Tal como salientado no Healio<\/em> Em discuss\u00e3o, os procedimentos aditivos da c\u00f3rnea, como o CAIRS, permanecem ajust\u00e1veis, revers\u00edveis e compat\u00edveis com outras interven\u00e7\u00f5es cir\u00fargicas, incluindo a adapta\u00e7\u00e3o de lentes esclerais e a cirurgia refractiva da catarata. O ECO-CAIRS alarga esta flexibilidade ao abordar a estabilidade biomec\u00e2nica, o risco de infe\u00e7\u00e3o e o controlo da implanta\u00e7\u00e3o ao n\u00edvel do tecido.<\/p>

Do ponto de vista do ELZA, a evolu\u00e7\u00e3o do CAIRS para o ECO-CAIRS reflecte uma mudan\u00e7a mais ampla nos cuidados com o ceratocone: passar de t\u00e9cnicas isoladas para percursos de tratamento biomecanicamente informados e espec\u00edficos para cada doente<\/span> que integram a estabiliza\u00e7\u00e3o, a remodela\u00e7\u00e3o e a reabilita\u00e7\u00e3o visual.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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O ECO-CAIRS alarga a cirurgia de ceratocone baseada em tecidos, optimizando os segmentos de anel alog\u00e9nicos atrav\u00e9s de reticula\u00e7\u00e3o extracorporal.<\/p>","protected":false},"author":4,"featured_media":51997,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[214,1,96],"tags":[1559,778,1557,561,725,1562,1561,993,361,1002,123,1560,1556,1563,1558],"class_list":["post-51989","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-farhad-hafezi","category-general-news","category-popular-press","tag-allogeneic-ring-segments","tag-cairs","tag-cornea-research","tag-corneal-ectasia","tag-corneal-surgery","tag-corneal-treatment-innovations","tag-customized-cairs","tag-eco-cairs","tag-farhad-hafezi","tag-healio","tag-keratoconus","tag-minimally-invasive-corneal-procedures","tag-rneal-allogenic-intrastromal-ring-segments","tag-shady-awwad","tag-surgical-evolution"],"acf":[],"yoast_head":"\nECO-CAIRS and the Evolution of Additive Keratoconus Surgery - 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