Best Poster Prize at Winter ESCRS 2020 is awarded to Emilio Torres-Netto

On September, 2019, Emilio Torres-Netto won the best poster prize (refractive section) at the ESCRS Annual meeting for his poster “Stromal bed smoothness after excimer laser surface ablation as a key element for the expression of inflammatory genes”. We are pleased to report that at the 2020 Winter ESCRS meeting in Marrakesh, Morocco, Dr. Torres-Netto won, once again, the same poster prize. Congratulations Dr. Torres-Netto!

The study he presented was a combination of the results of several years of basic research and data from a clinical study performed in Zurich, and it focused on improving how the laser interacts with the tissue with the objective of producing less inflammation during the procedure. This is important, as laser ablation of the corneal stroma – especially deep ablations, such as those required when treating high myopia and astigmatism – have the potential to cause significant corneal inflammation, and as part of the cornea’s wound healing response, corneal haze, which significantly slows the pace of patients’ visual recoveries.

Today, refractive surgeons use a drug called mitomycin C (MMC) to avoid developing haze, but this is a cytotoxic drug that intercalates with DNA and stops cells from proliferating, and the long-term consequences of using MMC are currently unknown.

Our researchers wanted to know whether using different laser ablation algorithms and optimised laser ablation profiles could alter the gene expression profiles of the ablated cornea, and they had a particular focus on genes that are involved with the inflammatory response.

What they found was that reductions in the inflammatory responses could be achieved by optimizing the laser ablation algorithms and energy settings, and that postoperative corneal smoothness appeared to be the key factor in regulating this immune response. To do so, they performed photorefractive keratectomy on rabbit corneas, using standard, high-fluence without optimization of corneal smoothness (OCS), low-fluence with OCS, and untreated controls, and examined the gene expression profiles 48 hours later using microarray gene expression analysis to identify genes that were expressed differently in treated and untreated corneas, followed by a technique called RT-PCR to validate those changes.

What Dr. Torres-Netto and his colleagues found that several pro-inflammatory genes were upregulated in the laser-treated corneas. Of note, they discovered that postoperative corneal smoothness was the key factor in inflammatory regulation – the smoother the cornea, the lower the inflammatory response, concluding that controlling stromal bed smoothness and thus, haze, may allow for deeper ablations, but also for the development of future ablation profiles that might broaden the indications of surface ablation to stromal depths currently only accessible with lamellar surgeries. What does this mean for patients? It is a simple message: surgeons should be able to correct more myopia using PRK that leaves the cornea smoother.

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Thunder Shiviah
Thunder Shiviah
14:05 23 Nov 21
After some research on local options I decided to go with ELZA since it stood out as the best. The operation and the... post-operation recovery went extremely smooth (something I was worried about with PRK). Now my vision is much better than I had hoped and I have no side effects such as dry eye or night vision problems. Thank you!read more
Squitieri Elias
Squitieri Elias
12:43 08 Sep 21
Die Behandlungen waren bei mir erfolgreich, alle waren sehr nett und haben mein Leben vereinfacht.Danke
Eliane Bossart
Eliane Bossart
13:01 05 Sep 21
Vor einem Jahr war ich einer ganz verzweifelten Situation und total im Stich gelassen. Meine Augen wurden aufgrund... eines ausgeprägten Kerakotonus immer schlechter, ich hatte Angst und war alleine mit meinen Problemen. Zudem vertrug ich die Kontaktlinsen nur noch ganz schlecht und hatte jeden Tag Schmerzen.Professor Hafezi hat mir mit zwei Operationen wieder das auf Grund der Situation mögliche an Lebensqualität zurückgebracht. Es war ein starpaziöses Jahr mit vielen Entbehrungen aber es hat sich gelohnt! Herzlichen Dank fuer die Unterstützung.read more
Gabriela Meyer
Gabriela Meyer
18:32 22 Aug 21
Ich wurde von meiner Optikerin auf Prof. Dr. Dr. Hafezi aufmerksam gemacht. Es war mir vorher nicht bewusst, dass meine... Augenkrankheit (Keratokonus) operativ mittels Cross Linking behandelt und so gestoppt werden kann. Die Beratung und Behandlung war sehr kompetent und ich fühlte mich jederzeit wohl. Die Operation verlief gut und das Ergebnis ist einwandfrei.read more
Naomi
Naomi
11:38 11 Aug 21
Ich bin sehr glücklich, dass ich das Elza Institute gefunden habe. Ich wurde von anderen Augenärzten abgewiesen, da... meine Augen zu kompliziert/schwierig zu behandeln waren. Prof. Dr. Dr. Hafezi konnte mir jedoch helfen und ich bin sehr glücklich und zufrieden mit dem Resultat. Vielen Dank!read more
Till B
Till B
08:30 19 Jul 21
Ich habe eine überaus kompetente Beratung und Behandlung erlebt. Die gesamte Betreuung war sehr freundlich und... professionell. Herzlichen Dank!read more
Thomas S.
Thomas S.
09:37 07 Jul 21
My left eye had to be operated on because of a cataract. As I had an Artiflex lens implanted a few years ago, it had to... be removed first before a modern lens could be implanted to correct the cataract. Prof. Hafezi treated me in an very competent and friendly manner. I am very happy with the result.read more
Selma A. Rahim
Selma A. Rahim
19:45 02 Jul 21
Dr. Hafezi.. the KING OF CXL🤴
Gianluca Ricci
Gianluca Ricci
12:46 10 Apr 21
Great team and service!
rehaneyecare
rehaneyecare
05:36 08 Apr 21
Excellent surgeon
Steven H.A
Steven H.A
16:13 11 Jan 21
Prof. F. Hafezi s expertise is enormous and he has a very pleasant and calm nature which gives the patient... security.Thank youread more
Online Commande
Online Commande
09:19 05 Dec 20
Totally creepy, very arrogant Prof.He just want your money.It may explain, why this Prof. is not in the center of the... city of Zürich and why he has been thrown away from University of Geneva.read more
Elena Churilova
Elena Churilova
10:06 17 Nov 20
At the moment, 3 months have passed since the moment I made laser vision correction in this clinic. and I can say that... I am happy that I chose this particular clinic and Prof. F. Hafezi. The entire staff of the clinic is very friendly, treats patients with sympathy and patience if they are nervous before surgery (my big gratitude to Aida Alili for all support and patience). The doctor Hafezi and other doctors of the clinic are very professional and ready to explain to you as many times as you need. I can only recommend!read more
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