Terrien’s marginal degeneration (TMD)

Terrien’s marginal corneal degeneration (TMD) is a rare bilateral progressive disease that dilutes the cornea. Usually this happens in middle to higher age.

Terrien’s disease can lead to progressive dilation of the cornea and corneal perforation. The treatment is a great challenge, and even corneal transplantation is difficult and often impossible

Can TMD be treated?

There is no causal therapy of Terrien’s disease of the cornea. A member of the ELZA Institute was able to publish a much-noticed report, which shows that the cross-linking procedure may stop and even partially reverse the thinning of the cornea in Terrien’s disease: the published case received a CXL in both eyes. The corneas of both eyes were then stable for years and the peripheral cornea was even slightly thicker (and thus more stable).

“We only treated two eyes, but it was the first time a Terrien could be stopped and partially reversed,” Farhad Hafezi, MD, PhD, OSN Europe Edition Board Member, said in a telephone interview with Ocular Surgery News

The ELZA Institute

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