Keratoconus and pregnancy

In pregnancy, very large changes in hormone concentrations take place, with the two most important being oestrogen and thyroid hormone.

Oestrogen

The female sex hormone estrogen is produced in pregnancy in much higher concentrations – and also leads to changes in the cornea, in particular, in the seventh and eighth month of pregnancy, when the concentration of this hormone in the blood increases 40,000-fold.

Estrogen prepares the female body for childbirth by softening connective tissue. Of course, this is very important for the birth process… but it also results in a softer cornea and this can massively increase a pre-existing keratoconus.

This research area is new and there are not yet many scientific publications on the subject. Some of the key publications come from our research group.

Oestrogen alters keratoconus during pregnancy

One of the first scientific descriptions ever was by our group in 2013, published in the Journal of Cataract and Refractive Surgery. In one woman with a keratoconus in her first pregnancy, we observed in one eye, temporary, and in the other eye, lasting changes – that even increased during the woman’s second pregnancy.

Thyroid hormone

Thyroid hormone also seems to play an important role in the mechanics of the cornea. It has been known for years that the risk of corneal disease increases when, for example, the thyroid gland has to be removed for a disease such as Hashimoto’s thyroiditis. But it has only been in recent years, that the evidence that thyroid hormone clearly affects the biomechanics of the cornea have truly become apparent.

Thyroid hormone is naturally reduced during pregnancy. At the University of Geneva from 2012 to 2014, Professor Hafezi a large-scale study where pregnant women were regularly examined throughout the pregnancy and in the first six months after birth. The researchers examined the hormone concentrations of oestrogen and thyroid hormone and compared and correlated these hormone levels with measurements made of the cornea during this time. The results appeared in the American Journal of Ophthalmology at the end of 2017 and clearly showed a clear link between hyperthyroidism and the cornea.

Hormones and the cornea

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Augeninstitut ELZA
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Squitieri Elias
Squitieri Elias
12:43 08 Sep 21
Die Behandlungen waren bei mir erfolgreich, alle waren sehr nett und haben mein Leben vereinfacht.Danke
Eliane Bossart
Eliane Bossart
13:01 05 Sep 21
Vor einem Jahr war ich einer ganz verzweifelten Situation und total im Stich gelassen. Meine Augen wurden aufgrund... eines ausgeprägten Kerakotonus immer schlechter, ich hatte Angst und war alleine mit meinen Problemen. Zudem vertrug ich die Kontaktlinsen nur noch ganz schlecht und hatte jeden Tag Schmerzen.Professor Hafezi hat mir mit zwei Operationen wieder das auf Grund der Situation mögliche an Lebensqualität zurückgebracht. Es war ein starpaziöses Jahr mit vielen Entbehrungen aber es hat sich gelohnt! Herzlichen Dank fuer die Unterstützung.read more
Gabriela Meyer
Gabriela Meyer
18:32 22 Aug 21
Ich wurde von meiner Optikerin auf Prof. Dr. Dr. Hafezi aufmerksam gemacht. Es war mir vorher nicht bewusst, dass meine... Augenkrankheit (Keratokonus) operativ mittels Cross Linking behandelt und so gestoppt werden kann. Die Beratung und Behandlung war sehr kompetent und ich fühlte mich jederzeit wohl. Die Operation verlief gut und das Ergebnis ist einwandfrei.read more
Naomi
Naomi
11:38 11 Aug 21
Ich bin sehr glücklich, dass ich das Elza Institute gefunden habe. Ich wurde von anderen Augenärzten abgewiesen, da... meine Augen zu kompliziert/schwierig zu behandeln waren. Prof. Dr. Dr. Hafezi konnte mir jedoch helfen und ich bin sehr glücklich und zufrieden mit dem Resultat. Vielen Dank!read more
Till B
Till B
08:30 19 Jul 21
Ich habe eine überaus kompetente Beratung und Behandlung erlebt. Die gesamte Betreuung war sehr freundlich und... professionell. Herzlichen Dank!read more
Thomas S.
Thomas S.
09:37 07 Jul 21
My left eye had to be operated on because of a cataract. As I had an Artiflex lens implanted a few years ago, it had to... be removed first before a modern lens could be implanted to correct the cataract. Prof. Hafezi treated me in an very competent and friendly manner. I am very happy with the result.read more
Selma A. Rahim
Selma A. Rahim
19:45 02 Jul 21
Dr. Hafezi.. the KING OF CXL🤴
Gianluca Ricci
Gianluca Ricci
12:46 10 Apr 21
Great team and service!
rehaneyecare
rehaneyecare
05:36 08 Apr 21
Excellent surgeon
Steven H.A
Steven H.A
16:13 11 Jan 21
Prof. F. Hafezi s expertise is enormous and he has a very pleasant and calm nature which gives the patient... security.Thank youread more
Online Commande
Online Commande
09:19 05 Dec 20
Totally creepy, very arrogant Prof.He just want your money.It may explain, why this Prof. is not in the center of the... city of Zürich and why he has been thrown away from University of Geneva.read more
Elena Churilova
Elena Churilova
10:06 17 Nov 20
At the moment, 3 months have passed since the moment I made laser vision correction in this clinic. and I can say that... I am happy that I chose this particular clinic and Prof. F. Hafezi. The entire staff of the clinic is very friendly, treats patients with sympathy and patience if they are nervous before surgery (my big gratitude to Aida Alili for all support and patience). The doctor Hafezi and other doctors of the clinic are very professional and ready to explain to you as many times as you need. I can only recommend!read more
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