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The Antibacterial Efficacy of High-Fluence PACK Cross-Linking Can Be Accelerated

The Antibacterial Efficacy of High-Fluence PACK Cross-Linking Can Be Accelerated

This month the article, “The Antibacterial Efficacy of High-Fluence PACK Cross-Linking Can Be Accelerated,” authored by ELZA’s Nan-Ji Lu et al., explores how photoactivated chromophore for keratitis-corneal cross-linking (PACK-CXL) as a treatment for infectious keratitis can be improved. Infectious keratitis is a common cause of ocular morbidity, can progress rapidly, and can extreme cases, cause the loss of the eye within days. Infectious keratitis is typically treated with antimicrobial agents. However, as antimicrobial resistance increases, it becomes more difficult to find effective treatment options. PACK-CXL involves saturating the cornea with a chromophore (usually riboflavin) and then photoactivating it with ultraviolet-A (UV-A) light. This generates reactive oxygen species, which have several effects, including increasing the stiffness of the cornea, making the cornea more resistant to digestion, as well as directly damaging pathogen cell membranes and nucleic acids. PACK-CXL is effective in killing bacteria and fungi in experiments and has also been effective both alone and in combination with standard-of-care antimicrobial therapy in clinical practice.

The article by Lu et al. reports an in vitro study, conducted to determine whether high-fluence PACK-CXL can be accelerated while still maintaining its antibacterial efficacy. The study found that high-fluence PACK-CXL did indeed decrease the bacterial concentration of several clinically significant bacterial strains, including S. aureusP. aeruginosa, and S. epidermidis. These strains are commonly implicated in bacterial keratitis and contact lens-associated keratitis. Furthermore, the authors found that higher total fluence PACK-CXL protocols led to a corresponding increase in bacterial killing ratio (BKR).

The study further reinforces the concept that high-fluence PACK-CXL can be used as an effective treatment for infectious keratitis, especially as accelerated high-fluence protocols are more convenient and comfortable for patients. Further studies are underway to determine the safety and efficacy of high-fluence accelerated PACK-CXL in clinical practice.

Reference

Lu NJ, Koliwer-Brandl H, Gilardoni F, et al. The antibacterial efficacy of high-fluence pack cross-linking can be accelerated. Transl Vis Sci Technol. 2023;12(2):12.

Click here to read the article.

High-Fluence PACK Cross-Linking Can Be Accelerated

 

 

 

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mike
09:02 04 Jan 23
Overall as a 50 year old, who wanted to continue to avoid wearing glasses and/or contact lenses, my goal was 100%... achieved with ELZA and Dr. Hafezi. I greatly appreciated the overall approach by Dr. Hafezi and his friendly and competent team in reviewing my vision at the start and following a comprehensive eye exam- the explanations of my options. For me I chose PRK in one eye for a monovision solution to correct short sightedness which was becoming more prevalent in night driving and sports such as skiing and cycling. PRK heals slowly but the outcome is worth the wait- and the cost- you use your eyes every waking moment- and for me I cannot see any reason not to pursue better vision with the ELZA team! A great quality of life enhancement!read more
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Zuzana Fecko
21:48 31 Oct 22
Thank you so much, Dr. Torres and prof. Hafezi. 26 years I was only “dreaming” about the eye surgery due to possible... complications. I was worried ..Thank you for encouraging me to make a decision and thank you for your professionalism, explanations and great work!I wish you all the best, lots of success and only happy patients!read more
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Serena Fazio
11:15 06 Mar 22
I have been to the ELZA clinic to have surgery for my miopy, as my eyes were rejecting the contacts and I was tired of... wearing glasses. From the first preliminary visit, to the actual surgery and post-surgery care Dr. Hafezi and all his collaborators have been extremely professional, considerate and helpful. All the steps of the (very short!) surgery were thoroughly explained to me in order to be as calm as possible, together with the medication plan and precautions to be aware of so that my eyes could heal in the best way possible. By following their exact instructions, the healing process has been very successful and smooth, and after about one week I was able to see perfectly. I absolutely recommend this team and their expertise!read more
Robin A
Robin A
11:43 16 Feb 22
Top experts and professional team. Highly recommended
Thunder Shiviah
Thunder Shiviah
14:05 23 Nov 21
After some research on local options I decided to go with ELZA since it stood out as the best. The operation and the... post-operation recovery went extremely smooth (something I was worried about with PRK). Now my vision is much better than I had hoped and I have no side effects such as dry eye or night vision problems. Thank you!read more
Thomas S.
Thomas S.
09:37 07 Jul 21
My left eye had to be operated on because of a cataract. As I had an Artiflex lens implanted a few years ago, it had to... be removed first before a modern lens could be implanted to correct the cataract. Prof. Hafezi treated me in an very competent and friendly manner. I am very happy with the result.read more
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19:45 02 Jul 21
Dr. Hafezi.. the KING OF CXL🤴
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Great team and service!
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Prof. F. Hafezi s expertise is enormous and he has a very pleasant and calm nature which gives the patient... security.Thank youread more
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Totally creepy, very arrogant Prof.He just want your money.It may explain, why this Prof. is not in the center of the... city of Zürich and why he has been thrown away from University of Geneva.read more
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Elena Churilova
10:06 17 Nov 20
At the moment, 3 months have passed since the moment I made laser vision correction in this clinic. and I can say that... I am happy that I chose this particular clinic and Prof. F. Hafezi. The entire staff of the clinic is very friendly, treats patients with sympathy and patience if they are nervous before surgery (my big gratitude to Aida Alili for all support and patience). The doctor Hafezi and other doctors of the clinic are very professional and ready to explain to you as many times as you need. I can only recommend!read more
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Michele Aggiato
18:17 10 Jan 20
The day I had Prof Hafezi checking my keratoconus I knew I was finally in the right place after years of searching for... a good ophthalmologist. Prof Hafezi recommended a surgery due to a drastic degeneration of my cornea. The surgery was performed by himself with the assistance of Dr Rodriguez, one more collaborator of Prof Hafezi’s team who got my full trust.read more
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Ashley Faulkes
15:30 21 Mar 16
Professor Hafezi and the team at the ELZA Institute have done an amazing job of creating a first class eye clinic, with... cutting edge technology and support. I went there for a dry eye issue and other issues with my prescription, and they were easily able to help me and put me on the road to better vision! High recommend them to anyone in the Zurich/Aargau area.read more
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