Suche
Close this search box.
Die antibakterielle Wirksamkeit des High-Fluence PACK Cross-Linking kann beschleunigt werden

Die antibakterielle Wirksamkeit des High-Fluence PACK Cross-Linking kann beschleunigt werden

In diesem Monat untersucht der Artikel "The Antibacterial Efficacy of High-Fluence PACK Cross-Linking Can Be Accelerated" (Die antibakterielle Wirksamkeit von High-Fluence PACK Cross-Linking kann beschleunigt werden), verfasst von Nan-Ji Lu et al. von ELZA, wie das photoaktivierte Chromophor für Keratitis-Corneal Cross-Linking (PACK-CXL) als Behandlung für die infektiöse Keratitis verbessert werden kann. Die infektiöse Keratitis ist eine häufige Ursache für Augenerkrankungen, die schnell fortschreiten und im Extremfall innerhalb weniger Tage zum Verlust des Auges führen kann. Die infektiöse Keratitis wird in der Regel mit antimikrobiellen Wirkstoffen behandelt. Mit der zunehmenden Resistenz gegen antimikrobielle Mittel wird es jedoch immer schwieriger, wirksame Behandlungsmöglichkeiten zu finden. Bei PACK-CXL wird die Hornhaut mit einem Chromophor (in der Regel Riboflavin) gesättigt und dann mit UV-A-Licht photoaktiviert. Dadurch werden reaktive Sauerstoffspezies erzeugt, die unter anderem die Steifigkeit der Hornhaut erhöhen, die Hornhaut widerstandsfähiger gegen Verdauung machen und die Zellmembranen und Nukleinsäuren von Krankheitserregern direkt schädigen. PACK-CXL tötet in Experimenten Bakterien und Pilze ab und hat sich auch in der klinischen Praxis sowohl allein als auch in Kombination mit einer antimikrobiellen Standardtherapie als wirksam erwiesen.

Der Artikel von Lu et al. berichtet von einer In-vitro -Studie, die durchgeführt wurde, um festzustellen, ob High-Fluence PACK-CXL beschleunigt werden kann, ohne seine antibakterielle Wirksamkeit zu verlieren. Die Studie ergab, dass High-Fluence PACK-CXL tatsächlich die bakterielle Konzentration mehrerer klinisch bedeutsamer Bakterienstämme, darunter S. aureusP. aeruginosa, und S. epidermidis, verringert. Diese Stämme werden häufig bei bakteriellen Keratitiden und Kontaktlinsen-assoziierten Keratitiden vorgefunden. Darüber hinaus stellten die Autoren fest, dass PACK-CXL-Protokolle mit höherer Gesamtfluenz zu einem entsprechenden Anstieg der Bakterienabtötungsrate (BKR) führten.

Die Studie untermauert das Konzept, dass PACK-CXL mit hoher Fluenz als wirksame Behandlung für die infektiöse Keratitis eingesetzt werden kann, zumal beschleunigte Protokolle mit hoher Fluenz für die Patienten bequemer und angenehmer sind. Weitere Studien sind im Gange, um die Sicherheit und Wirksamkeit von beschleunigtem PACK-CXL mit hoher Fluenz in der klinischen Praxis zu bestimmen.

Referenz

Lu NJ, Koliwer-Brandl H, Gilardoni F, et al. The antibacterial efficacy of high-fluence pack cross-linking can be accelerated. Transl Vis Sci Technol. 2023;12(2):12.

Klicken Sie hier, um den Artikel zu lesen.

High-Fluence-PACK-Vernetzung kann beschleunigt werden

 

 

 

Das ELZA Institute

Suche
Close this search box.
EN | DE | PT
.
.
Augeninstitut ELZA
4.8
Basierend auf 109 Bewertungen
powered by Google
mike
mike
09:02 04 Jan 23
Overall as a 50 year old, who wanted to continue to avoid wearing glasses and/or contact lenses, my goal was 100%... achieved with ELZA and Dr. Hafezi. I greatly appreciated the overall approach by Dr. Hafezi and his friendly and competent team in reviewing my vision at the start and following a comprehensive eye exam- the explanations of my options. For me I chose PRK in one eye for a monovision solution to correct short sightedness which was becoming more prevalent in night driving and sports such as skiing and cycling. PRK heals slowly but the outcome is worth the wait- and the cost- you use your eyes every waking moment- and for me I cannot see any reason not to pursue better vision with the ELZA team! A great quality of life enhancement!weiterlesen
Zuzana Fecko
Zuzana Fecko
21:48 31 Oct 22
Thank you so much, Dr. Torres and prof. Hafezi. 26 years I was only “dreaming” about the eye surgery due to possible... complications. I was worried ..Thank you for encouraging me to make a decision and thank you for your professionalism, explanations and great work!I wish you all the best, lots of success and only happy patients!weiterlesen
Serena Fazio
Serena Fazio
11:15 06 Mar 22
I have been to the ELZA clinic to have surgery for my miopy, as my eyes were rejecting the contacts and I was tired of... wearing glasses. From the first preliminary visit, to the actual surgery and post-surgery care Dr. Hafezi and all his collaborators have been extremely professional, considerate and helpful. All the steps of the (very short!) surgery were thoroughly explained to me in order to be as calm as possible, together with the medication plan and precautions to be aware of so that my eyes could heal in the best way possible. By following their exact instructions, the healing process has been very successful and smooth, and after about one week I was able to see perfectly. I absolutely recommend this team and their expertise!weiterlesen
Robin A
Robin A
11:43 16 Feb 22
Top experts and professional team. Highly recommended
Thunder Shiviah
Thunder Shiviah
14:05 23 Nov 21
After some research on local options I decided to go with ELZA since it stood out as the best. The operation and the... post-operation recovery went extremely smooth (something I was worried about with PRK). Now my vision is much better than I had hoped and I have no side effects such as dry eye or night vision problems. Thank you!weiterlesen
Thomas S.
Thomas S.
09:37 07 Jul 21
My left eye had to be operated on because of a cataract. As I had an Artiflex lens implanted a few years ago, it had to... be removed first before a modern lens could be implanted to correct the cataract. Prof. Hafezi treated me in an very competent and friendly manner. I am very happy with the result.weiterlesen
Selma A. Rahim
Selma A. Rahim
19:45 02 Jul 21
Dr. Hafezi.. the KING OF CXL🤴
Gianluca Ricci
Gianluca Ricci
12:46 10 Apr 21
Great team and service!
rehaneyecare
rehaneyecare
05:36 08 Apr 21
Excellent surgeon
Steven H.A
Steven H.A
16:13 11 Jan 21
Prof. F. Hafezi s expertise is enormous and he has a very pleasant and calm nature which gives the patient... security.Thank youweiterlesen
Online Commande
Online Commande
09:19 05 Dec 20
Totally creepy, very arrogant Prof.He just want your money.It may explain, why this Prof. is not in the center of the... city of Zürich and why he has been thrown away from University of Geneva.weiterlesen
Elena Churilova
Elena Churilova
10:06 17 Nov 20
At the moment, 3 months have passed since the moment I made laser vision correction in this clinic. and I can say that... I am happy that I chose this particular clinic and Prof. F. Hafezi. The entire staff of the clinic is very friendly, treats patients with sympathy and patience if they are nervous before surgery (my big gratitude to Aida Alili for all support and patience). The doctor Hafezi and other doctors of the clinic are very professional and ready to explain to you as many times as you need. I can only recommend!weiterlesen
Michele Aggiato
Michele Aggiato
18:17 10 Jan 20
The day I had Prof Hafezi checking my keratoconus I knew I was finally in the right place after years of searching for... a good ophthalmologist. Prof Hafezi recommended a surgery due to a drastic degeneration of my cornea. The surgery was performed by himself with the assistance of Dr Rodriguez, one more collaborator of Prof Hafezi’s team who got my full trust.weiterlesen
Ashley Faulkes
Ashley Faulkes
15:30 21 Mar 16
Professor Hafezi and the team at the ELZA Institute have done an amazing job of creating a first class eye clinic, with... cutting edge technology and support. I went there for a dry eye issue and other issues with my prescription, and they were easily able to help me and put me on the road to better vision! High recommend them to anyone in the Zurich/Aargau area.weiterlesen
Mehr Bewertungen
js_loader
Augeninstitut ELZA
4.8
Basierend auf 109 Bewertungen
powered by Google
js_loader