Pellucid marginal degeneration (PMD) is member of the corneal ectasia family, such as keratoconus and post-LASIK ectasia. However, it differs from keratoconus in 3 essential ways:
CXL can also be successfully used in PMD, but it is sometimes necessary to repeat CXL after 6 or 12 months.
Cross-linking in PMD is similar to keratoconus but with one important difference: the cornea needs to be irradiated in an “eccentric” (off-centred) pattern, which exposes corneal stem cells to UV light. It has been unclear for years whether it is possible to irradiate these stem cells with UV light without damaging them and causing serious consequences for the eye. Our research group has shown in a series of elaborate experiments that this is indeed possible.
In advanced cases, the cornea is so thin that a standard CXL can no longer be used. This is where our extensive experience of treating extremely thin corneas comes to bear.
Read more about cross-linking thin corneas here.
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