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corneal-enzymatic-digestion-featured-image showing petri dishes with corneal buttons being digested by collagenases

Ein besserer Weg zur Verbesserung der Widerstandsfähigkeit der Hornhaut gegen die eznymatische Verdauung?

A recent publication in Translational Vision Science & Technology, titled “Combining Riboflavin/UV-A Light and Rose Bengal/Green Light Corneal Cross-Linking Increases the Resistance of Corneal Enzymatic Digestion” by the ELZA Institute’s M. Enes Aydemir and colleagues, presents an insightful study into corneal cross-linking (CXL), and how performing sequential corneal cross-linking with riboflavin/UV and rose bengal/green light protocols can increase corneal enzymatic digestion resistance greater than each protocol on its own.

Im Mittelpunkt der Studie stand die Frage, ob die gleichzeitige Anwendung von Riboflavin/UV-A-Licht (RF/UV-A) und Rose Bengal/Grünlicht (RB/Grün) in Epi-off PACK-CXL die Widerstandsfähigkeit der Hornhaut gegenüber enzymatischer Verdauung im Vergleich zu separaten Chromophor/Licht-Behandlungen verbessern kann. Durchgeführt in ex vivo Schweinehornhäuten durchgeführt wurde, war methodisch in drei Gruppen gegliedert, die jeweils unterschiedlichen Graden von RF- und RB-Behandlungen mit und ohne Lichtexposition unterzogen wurden. Die Ergebnisse zeigten, dass die Hornhäute, die mit der kombinierten RF/UV-A- und RB/Grün-Methode behandelt wurden, eine deutlich höhere Resistenz gegenüber enzymatischer Verdauung aufwiesen als die separat behandelten.

Die Ergebnisse dieser Studie sind vor allem im Zusammenhang mit infektiöser Keratitis (IK) von Bedeutung, einer der Hauptursachen für Erblindung weltweit. Die bei der kombinierten Behandlung festgestellte erhöhte Widerstandsfähigkeit gegenüber enzymatischer Verdauung deutet auf ein Potenzial für eine verbesserte Behandlungswirksamkeit bei IK hin, insbesondere in Fällen, in denen herkömmliche Therapien weniger wirksam sind. Die Studie geht davon aus, dass diese erhöhte Widerstandsfähigkeit der Hornhaut in klinischen Szenarien zu kleineren Geschwüren führen könnte, was für die Genesung der Patienten entscheidend ist.

Darüber hinaus unterstreicht die Studie die potenziellen translationalen Auswirkungen dieses kombinierten CXL-Ansatzes. Die Studie deutet darauf hin, dass diese Methode die Widerstandsfähigkeit der Hornhaut gegen Kollagenase-Verdauung, einen Schlüsselfaktor für das Fortschreiten der IK, deutlich stärken könnte. Dieser Einblick in die synergistische Wirkung von RF/UV-A und RB/Grünlicht bei CXL bietet eine wertvolle Perspektive für zukünftige therapeutische Strategien bei Hornhauterkrankungen, insbesondere angesichts der zunehmenden antimikrobiellen Resistenz.

Zusammenfassend lässt sich sagen, dass die Forschung von Aydemir et al. einen bedeutenden Beitrag zum Gebiet der Augenheilkunde leistet, insbesondere im Bereich der Behandlung von Hornhauterkrankungen. Der kombinierte RF/UV-A- und RB/Grünlicht-Ansatz in PACK-CXL stellt eine vielversprechende Richtung für die künftige Forschung und klinische Anwendung dar und könnte die Behandlung und die Ergebnisse der infektiösen Keratitis verbessern.

Repräsentatives Bild einer 24-Well-Platte mit Hornhäuten unmittelbar nach dem Eintauchen in 0,3 %ige Kollagenaselösung (A) und nach 25 Stunden (B) Verdauung in 0,3 %iger Kollagenaselösung A sowie am Endpunkt (C).

Das ELZA Institute

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Augeninstitut ELZA
4.8
Basierend auf 109 Bewertungen
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mike
mike
09:02 04 Jan 23
Overall as a 50 year old, who wanted to continue to avoid wearing glasses and/or contact lenses, my goal was 100%... achieved with ELZA and Dr. Hafezi. I greatly appreciated the overall approach by Dr. Hafezi and his friendly and competent team in reviewing my vision at the start and following a comprehensive eye exam- the explanations of my options. For me I chose PRK in one eye for a monovision solution to correct short sightedness which was becoming more prevalent in night driving and sports such as skiing and cycling. PRK heals slowly but the outcome is worth the wait- and the cost- you use your eyes every waking moment- and for me I cannot see any reason not to pursue better vision with the ELZA team! A great quality of life enhancement!weiterlesen
Zuzana Fecko
Zuzana Fecko
21:48 31 Oct 22
Thank you so much, Dr. Torres and prof. Hafezi. 26 years I was only “dreaming” about the eye surgery due to possible... complications. I was worried ..Thank you for encouraging me to make a decision and thank you for your professionalism, explanations and great work!I wish you all the best, lots of success and only happy patients!weiterlesen
Serena Fazio
Serena Fazio
11:15 06 Mar 22
I have been to the ELZA clinic to have surgery for my miopy, as my eyes were rejecting the contacts and I was tired of... wearing glasses. From the first preliminary visit, to the actual surgery and post-surgery care Dr. Hafezi and all his collaborators have been extremely professional, considerate and helpful. All the steps of the (very short!) surgery were thoroughly explained to me in order to be as calm as possible, together with the medication plan and precautions to be aware of so that my eyes could heal in the best way possible. By following their exact instructions, the healing process has been very successful and smooth, and after about one week I was able to see perfectly. I absolutely recommend this team and their expertise!weiterlesen
Robin A
Robin A
11:43 16 Feb 22
Top experts and professional team. Highly recommended
Thunder Shiviah
Thunder Shiviah
14:05 23 Nov 21
After some research on local options I decided to go with ELZA since it stood out as the best. The operation and the... post-operation recovery went extremely smooth (something I was worried about with PRK). Now my vision is much better than I had hoped and I have no side effects such as dry eye or night vision problems. Thank you!weiterlesen
Thomas S.
Thomas S.
09:37 07 Jul 21
My left eye had to be operated on because of a cataract. As I had an Artiflex lens implanted a few years ago, it had to... be removed first before a modern lens could be implanted to correct the cataract. Prof. Hafezi treated me in an very competent and friendly manner. I am very happy with the result.weiterlesen
Selma A. Rahim
Selma A. Rahim
19:45 02 Jul 21
Dr. Hafezi.. the KING OF CXL🤴
Gianluca Ricci
Gianluca Ricci
12:46 10 Apr 21
Great team and service!
rehaneyecare
rehaneyecare
05:36 08 Apr 21
Excellent surgeon
Steven H.A
Steven H.A
16:13 11 Jan 21
Prof. F. Hafezi s expertise is enormous and he has a very pleasant and calm nature which gives the patient... security.Thank youweiterlesen
Online Commande
Online Commande
09:19 05 Dec 20
Totally creepy, very arrogant Prof.He just want your money.It may explain, why this Prof. is not in the center of the... city of Zürich and why he has been thrown away from University of Geneva.weiterlesen
Elena Churilova
Elena Churilova
10:06 17 Nov 20
At the moment, 3 months have passed since the moment I made laser vision correction in this clinic. and I can say that... I am happy that I chose this particular clinic and Prof. F. Hafezi. The entire staff of the clinic is very friendly, treats patients with sympathy and patience if they are nervous before surgery (my big gratitude to Aida Alili for all support and patience). The doctor Hafezi and other doctors of the clinic are very professional and ready to explain to you as many times as you need. I can only recommend!weiterlesen
Michele Aggiato
Michele Aggiato
18:17 10 Jan 20
The day I had Prof Hafezi checking my keratoconus I knew I was finally in the right place after years of searching for... a good ophthalmologist. Prof Hafezi recommended a surgery due to a drastic degeneration of my cornea. The surgery was performed by himself with the assistance of Dr Rodriguez, one more collaborator of Prof Hafezi’s team who got my full trust.weiterlesen
Ashley Faulkes
Ashley Faulkes
15:30 21 Mar 16
Professor Hafezi and the team at the ELZA Institute have done an amazing job of creating a first class eye clinic, with... cutting edge technology and support. I went there for a dry eye issue and other issues with my prescription, and they were easily able to help me and put me on the road to better vision! High recommend them to anyone in the Zurich/Aargau area.weiterlesen
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Augeninstitut ELZA
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