Prof Hafezi CRST Innovation in Switzerland

Update zum Fortschritt im Corneal Cross-Linking: Schweiz

Ein Artikel von Prof. Dr. Farhad Hafezi,, MD, PhD, FARVO, dem medizinischen Direktor des ELZA Institutes, der in der November/Dezember-Ausgabe von Cataract and Refractive Surgery Today veröffentlicht wurde,beschreibt die neuesten Fortschritte bei der Forschung zum Hornhaut-Kollagen-Cross-Linking (CXL). Die Schweiz und insbesondere Zürich sind seit über zwei Jahrzehnten im Bereich der CXL-Innovation führend. In den letzten 20 Jahren haben die meisten Chirurgen die Epithel-off (epi-off) CXL-Prozedur nach dem Dresden-Protokoll (das eine UV-Bestrahlung mit einer Intensität von 3 mW/cm² für 30 Minuten erfordert) oder ein beschleunigtes Cross-Linking-Protokoll (9 mW/cm² für 10 Minuten) durchgeführt. Das Beschleunigen der Prozedur ist für Arzt und Patient bequem, aber je mehr die Prozedur beschleunigt wird, desto geringer ist die spätere Stärkungswirkung auf die Hornhaut. Prof. Hafezi und sein Team haben jedoch ein neues epi-off CXL-Protokoll entwickelt, das ähnliche Hornhautverstärkungswirkungen wie das Dresden-Protokoll liefert, aber in einer kürzeren Dauer. 


Das Team führte eine UV-Bestrahlung mit einer Intensität von 18 mW/cm² für 9 Minuten und 15 Sekunden durch, was eine UV-Fluenz von 10 J/cm² im Vergleich zu den traditionellen 5,4 J/cm² im Dresden-Protokoll und fast allen bisher verwendeten beschleunigten Protokollen liefert. Die Laborergebnisse dieses neuen Protokolls zeigen, dass die Hornhautversteifungseffekte wirksam und vergleichbar mit dem Dresden-Protokoll sind, ohne dass weitere Modifikationen der CXL-Prozedur als UV-Bestrahlungseinstellungen erforderlich sind.

Darüber hinaus hat das Team auch ein Epithel-on (epi-on) CXL-Protokoll entwickelt, das eine Riboflavin-Lösung mit Penetrationverstärkern verwendet, anstatt dass zusätzliches Sauerstoff oder Iontophorese erforderlich ist. Die Laborergebnisse dieses neuen Protokolls zeigen ähnliche Hornhautversteifungseffekte wie epi-off CXL mit einem beschleunigten Protokoll von 9 mW/cm² für 10 Minuten. Einer der Hauptvorteile dieses neuen Protokolls besteht darin, dass es die potenziellen Nachteile vermeidet, die mit der Entfernung und Neubildung des Epithels verbunden sind.

Darüber hinaus untersucht das Team von Prof. Hafezi auch neue Methoden, um die Behandlungsoptionen für Keratokonus und infektiöse Keratitis zu verbessern. Sie haben Zugang zu hochmodernen Instrumenten zur Bewertung der biomechanischen Eigenschaften der Hornhaut, wie dem hochgeschwindigkeits-Luftstoß-Hornhautdeformationsgerät, dem CorVis ST und dem Brillouin Optical Scanner System, die das Potenzial haben, neue Einsichten zum Keratokonus zu gewinnen. Zusätzlich arbeitet das Team daran, die photoaktivierte Chromophor-Technik für die Keratitis-CXL (PACK-CXL) zu verbessern und hat bereits festgestellt, dass höhere Fluenzen als die 5,4 J/cm² des Dresden-Protokolls erforderlich sein können, um viele Fälle von infektiöser Keratitis erfolgreich zu behandeln.

Zusammenfassend hebt der Artikel mehrere vielversprechende Fortschritte in der CXL-Forschung durch Prof. Farhad Hafezi und sein Team am ELZA Institute in der Schweiz und dem Center for Applied Biotechnology and Molecular Medicine (CABMM) der Universität Zürich vor. Ihre Arbeit am Epi-on-CXL, dem neuen Epi-off-CXL-Protokoll und PACK-CXL verspricht viel für die Zukunft. Center for Applied Biotechnology and Molecular Medicine (CABMM). Their work on epi-on CXL, the new epi-off CXL protocol and PACK-CXL hold much promise for the future.

Das ELZA Institute

EN | DE | PT
.
.
4.8
Basierend auf 109 Bewertungen
powered by Google
mike
09:02 04 Jan 23
Overall as a 50 year old, who wanted to continue to avoid wearing glasses and/or contact lenses, my goal was 100% achieved with ELZA and Dr. Hafezi. I greatly appreciated the overall approach by Dr. Hafezi and his friendly and competent team in reviewing my vision at the start and following a comprehensive eye exam- the explanations of my options. For me I chose PRK in one eye for a monovision solution to correct short sightedness which was becoming more prevalent in night driving and sports such as skiing and cycling. PRK heals slowly but the outcome is worth the wait- and the cost- you use your eyes every waking moment- and for me I cannot see any reason not to pursue better vision with the ELZA team! A great quality of life enhancement!
Zuzana Fecko
21:48 31 Oct 22
Thank you so much, Dr. Torres and prof. Hafezi. 26 years I was only “dreaming” about the eye surgery due to possible complications. I was worried ..Thank you for encouraging me to make a decision and thank you for your professionalism, explanations and great work!I wish you all the best, lots of success and only happy patients!
Serena Fazio
11:15 06 Mar 22
I have been to the ELZA clinic to have surgery for my miopy, as my eyes were rejecting the contacts and I was tired of wearing glasses. From the first preliminary visit, to the actual surgery and post-surgery care Dr. Hafezi and all his collaborators have been extremely professional, considerate and helpful. All the steps of the (very short!) surgery were thoroughly explained to me in order to be as calm as possible, together with the medication plan and precautions to be aware of so that my eyes could heal in the best way possible. By following their exact instructions, the healing process has been very successful and smooth, and after about one week I was able to see perfectly. I absolutely recommend this team and their expertise!
Robin A
11:43 16 Feb 22
Top experts and professional team. Highly recommended
Thunder Shiviah
14:05 23 Nov 21
After some research on local options I decided to go with ELZA since it stood out as the best. The operation and the post-operation recovery went extremely smooth (something I was worried about with PRK). Now my vision is much better than I had hoped and I have no side effects such as dry eye or night vision problems. Thank you!
Thomas S.
09:37 07 Jul 21
My left eye had to be operated on because of a cataract. As I had an Artiflex lens implanted a few years ago, it had to be removed first before a modern lens could be implanted to correct the cataract. Prof. Hafezi treated me in an very competent and friendly manner. I am very happy with the result.
Selma A. Rahim
19:45 02 Jul 21
Dr. Hafezi.. the KING OF CXL🤴
Gianluca Ricci
12:46 10 Apr 21
Great team and service!
rehaneyecare
05:36 08 Apr 21
Excellent surgeon
Steven H.A
16:13 11 Jan 21
Prof. F. Hafezi s expertise is enormous and he has a very pleasant and calm nature which gives the patient security.Thank you
Online Commande
09:19 05 Dec 20
Totally creepy, very arrogant Prof.He just want your money.It may explain, why this Prof. is not in the center of the city of Zürich and why he has been thrown away from University of Geneva.
Elena Churilova
10:06 17 Nov 20
At the moment, 3 months have passed since the moment I made laser vision correction in this clinic. and I can say that I am happy that I chose this particular clinic and Prof. F. Hafezi. The entire staff of the clinic is very friendly, treats patients with sympathy and patience if they are nervous before surgery (my big gratitude to Aida Alili for all support and patience). The doctor Hafezi and other doctors of the clinic are very professional and ready to explain to you as many times as you need. I can only recommend!
Michele Aggiato
18:17 10 Jan 20
The day I had Prof Hafezi checking my keratoconus I knew I was finally in the right place after years of searching for a good ophthalmologist. Prof Hafezi recommended a surgery due to a drastic degeneration of my cornea. The surgery was performed by himself with the assistance of Dr Rodriguez, one more collaborator of Prof Hafezi’s team who got my full trust.
Ashley Faulkes
15:30 21 Mar 16
Professor Hafezi and the team at the ELZA Institute have done an amazing job of creating a first class eye clinic, with cutting edge technology and support. I went there for a dry eye issue and other issues with my prescription, and they were easily able to help me and put me on the road to better vision! High recommend them to anyone in the Zurich/Aargau area.
Mehr Bewertungen
4.8
Basierend auf 109 Bewertungen
powered by Google